Partial reversal of the effect of maternal care on cognitive function through environmental enrichment
Partial reversal of the effect of maternal care on cognitive function through environmental enrichment
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DOI：
10.1016/s0306-4522(02)00918-1
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发表时间：
2003-01-01
期刊：
影响因子：
3.3
通讯作者：
Meaney, MJ
中科院分区：
文献类型：
--
作者：
Bredy, TW;Humpartzoomian, RA;Meaney, MJ
母爱影响大鼠的海马区发育。表现出幼崽舔/梳理和弓背哺育水平增加的母亲(高LG-ABN母亲)的后代显示出海马N-甲基-D-天冬氨酸(NMDA)受体结合增加，并增强了海马区依赖的空间学习。在这些研究中，我们研究了从出生22天到70天的环境丰富是否可能逆转低产妇护理的影响。环境丰富消除了高LG-ABN和低LG-ABN母亲的后代在Morris水迷宫学习和物体识别方面的差异。然而，丰富并不能逆转母爱对齿状回长时程增强或对海马NMDA受体结合的影响。相反，青春期前的丰富确实逆转了母亲照料对海马区a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic酸受体结合的影响。这些发现提供了证据，证明了母亲在早期生活中减少投资对成年后认知功能的影响是相反的。这种影响可能涉及与青春期周围丰富相关的代偿性变化。(C)2003年IBRO。爱思唯尔科学有限公司出版。版权所有。
Maternal care influences hippocampal development in the rat. The offspring of mothers that exhibit increased levels of pup licking/grooming and arched-back nursing (High LG-ABN mothers) show increased hippocampal N-methyl-D-aspartate (NMDA) receptor binding and enhanced hippocampal-dependent spatial learning. In these studies we examined whether environmental enrichment from days 22-70 of life might reverse the effects of low maternal care. Environmental enrichment eliminated the differences between the offspring of High and Low LG-ABN mothers in both Morris water maze learning and object recognition. However, enrichment did not reverse the effect of maternal care on long-term potentiation in the dentate gyrus or on hippocampal NMDA receptor binding. In contrast, peripubertal enrichment did reverse the effects of maternal care on hippocampal a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor binding. These findings provide evidence for the reversal of the effects of reduced maternal investment in early life on cognitive function in adulthood. Such effects might involve compensatory changes associated with peripubertal enrichment. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.