Human embryonic genes re-expressed in cancer cells
Human embryonic genes re-expressed in cancer cells
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DOI：
10.1038/sj.onc.1205088
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发表时间：
2001-12-06
期刊：
影响因子：
8
通讯作者：
Holding, C
中科院分区：
文献类型：
--
作者：
Monk, M;Holding, C
人类植入前胚胎细胞在表型上与癌细胞相似。这两种类型的细胞都经历了脱编程到增殖干细胞状态，并变得潜在的不朽和侵袭性。为了研究胚胎基因在癌细胞中重新表达的假设，我们从人个体植入前胚胎中制备了扩增的cDNA，并分离出胚胎特异序列。我们发现三个新的胚胎基因，以及已知的基因OCT4，在人类肿瘤中表达，但在正常体细胞组织中不表达。特定于人类生命周期这一独特阶段且不在体细胞中表达的基因可能在癌症治疗中具有更大的靶向潜力。
Human preimplantation embryonic cells are similar in phenotype to cancer cells. Both types of cell undergo deprogramming to a proliferative stem cell state and become potentially immortal and invasive. To investigate the hypothesis that embryonic genes are re-expressed in cancer cells, we prepare amplified cDNA from human individual preimplantation embryos and isolate embryo-specific sequences. We show that three novel embryonic genes, and also the known gene, OCT4, are expressed in human tumours but not expressed in normal somatic tissues. Genes specific to this unique phase of the human life cycle and not expressed in somatic cells may have greater potential for targeting in cancer treatment.