Osseointegration of zirconia implants compared with titanium: an in vivo study.
Osseointegration of zirconia implants compared with titanium: an in vivo study.
复制标题
DOI：
10.1186/1746-160x-4-30
复制
发表时间：
2008-12-11
影响因子：
3
通讯作者：
Handschel J
中科院分区：
文献类型：
--
作者：
Depprich R;Zipprich H;Ommerborn M;Naujoks C;Wiesmann HP;Kiattavorncharoen S;Lauer HC;Meyer U;Kübler NR;Handschel J
钛和钛合金广泛用于制造牙种植体。由于生物材料的材料成分和表面形貌在骨整合中发挥着重要作用，因此已经开发了各种化学和物理表面修饰来改善骨愈合。氧化锆基种植体作为钛种植体的替代品被引入牙科种植学。氧化锆似乎是一种合适的植入材料，因为它具有牙齿般的颜色、机械性能和生物相容性。由于氧化锆种植体的骨整合尚未得到广泛研究，本研究的目的是比较氧化锆种植体与钛种植体的骨愈合情况，钛种植体表面粗糙，但种植体几何形状相似。 12 只小型猪的胫骨中植入了 48 个氧化锆和钛植入物。 1、4或12周后，处死动物并根据组织学和超微结构技术检查含有植入物的样本。组织学结果显示氧化锆和钛表面上有直接骨接触。通过组织形态计量学测量，钛表面上的骨植入物接触略好于氧化锆表面。然而，两组之间没有观察到统计学上的显着差异。结果表明，表面经过修饰的氧化锆种植体可实现与钛种植体相当的骨整合。
Titanium and titanium alloys are widely used for fabrication of dental implants. Since the material composition and the surface topography of a biomaterial play a fundamental role in osseointegration, various chemical and physical surface modifications have been developed to improve osseous healing. Zirconia-based implants were introduced into dental implantology as an altenative to titanium implants. Zirconia seems to be a suitable implant material because of its tooth-like colour, its mechanical properties and its biocompatibility. As the osseointegration of zirconia implants has not been extensively investigated, the aim of this study was to compare the osseous healing of zirconia implants with titanium implants which have a roughened surface but otherwise similar implant geometries. Forty-eight zirconia and titanium implants were introduced into the tibia of 12 minipigs. After 1, 4 or 12 weeks, animals were sacrificed and specimens containing the implants were examined in terms of histological and ultrastructural techniques. Histological results showed direct bone contact on the zirconia and titanium surfaces. Bone implant contact as measured by histomorphometry was slightly better on titanium than on zirconia surfaces. However, a statistically significant difference between the two groups was not observed. The results demonstrated that zirconia implants with modified surfaces result in an osseointegration which is comparable with that of titanium implants.