Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis
Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis
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DOI：
10.1046/j.1523-1747.1998.00277.x
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发表时间：
1998-08-01
影响因子：
6.5
通讯作者：
Paus, R
中科院分区：
文献类型：
--
作者：
Botchkarev, VA;Botchkareva, NV;Paus, R
毛囊上皮和神经系统具有共同的外胚层起源，一些神经营养因子可调节角质形成细胞的增殖和凋亡。因此，我们有理由问，控制神经发育的生长因子是否也参与毛囊形态发生的调节。集中在神经营养因子-3（NT-3）和它的高亲和力受体[酪氨酸激酶C（TrkC）]，我们发现，在小鼠毛囊形态发生的早期，毛基板角质形成细胞表达TrkC mRNA和免疫反应性。在毛囊发育的后期阶段，TrkC mRNA，TrkC-和NT-3-免疫反应性可见于近端毛球的角质形成细胞以及毛乳头成纤维细胞中。与相应的野生型动物相比，毛囊形态发生的早期阶段在新生NT-3过表达小鼠中显著加速，而在新生杂合NT-3敲除（+/-）小鼠中这些被延迟。这些观察结果表明，NT-3是一个重要的生长调节剂在形态发生和神经外胚层间充质相互作用系统，如毛囊重塑。
Hair follicle epithelium and nervous system share a common ectodermal origin, and some neurotrophins can modulate keratinocyte proliferation and apoptosis. It is therefore reasonable to ask whether growth factors that control neural development are also involved in the regulation of hair follicle morphogenesis. Focusing on neurotrophin-3 (NT-3) and its high-affinity-receptor [tyrosine kinase C (TrkC)], we show that hair placode keratinocytes express TrkC mRNA and immunoreactivity early during murine hair follicle morphogenesis. In later stages of hair follicle development, TrkC mRNA, TrkC-, and NT-3-immunoreactivity are seen in keratinocytes of the proximal hair bulb as well as in dermal papilla fibroblasts. Compared with the corresponding wild-type animals, early stages of hair follicle morphogenesis are significantly accelerated in newborn NT-3 overexpressing mice, whereas these are retarded in newborn heterozygous NT-3 knockout (+/-) mice. These observations suggest that NT-3 is an important growth modulator during morphogenesis and remodeling of neuroectodermal-mesenchymal interaction systems like the hair follicle.