In vivo utilization of oxygen and glucose by neoplastic tissue.
In vivo utilization of oxygen and glucose by neoplastic tissue.
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肿瘤组织在体内利用氧和葡萄糖。
DOI：
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发表时间：
1976
影响因子：
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通讯作者：
P. Gullino
中科院分区：
文献类型：
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作者：
P. Gullino
瓦尔堡首先强调了氧利用和葡萄糖消耗在肿瘤存活和生长中的生物学作用（1，2）。多年来，该领域的实验方法依赖于测压技术、组织切片和匀浆。研究者最关注的是有氧糖酵解作为肿瘤转化的一种病变特征。直到1961年（3）才开发出一种肿瘤制剂，可以按照标准生理程序在体内测量实体瘤的氧和葡萄糖消耗（4-9）。
The biological role of oxygen utilization and glucose consumption in the survival and growth of tumors was first emphasized by Warburg (1,2). For many years the experimental approach in this field relied upon manometric techniques, tissue slices, and homogenates. The overriding preoccupation of investigators was the aerobic glycolysis as a lesion pathognomonic of neoplastic transformation. Only in 1961 (3) was a tumor preparation developed which permitted measurements of oxygen and glucose consumption by solid tumors in vivo following standard physiological procedures (4–9).