Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children
Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children
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DOI：
10.1086/521195
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发表时间：
2007-10-01
影响因子：
6.4
通讯作者：
Ko, GwangPyo
中科院分区：
文献类型：
--
作者：
Long, Kurt Z.;Garcia, Coralith;Ko, GwangPyo
背景。维生素A补充剂对生活在发展中国家的幼儿病毒性胃肠道感染的影响尚不清楚。1998年6月至8月，在一项随机、安慰剂对照试验中，研究了127名5-15个月大的墨西哥儿童补充维生素A对诺如病毒（NoV）感染的影响。每2周和腹泻后收集粪便样本进行NoV筛查，并在基因组水平（GI和GII）上进行特征分析。在收集的粪便样本中，29.9%为NoV阳性，阳性样本中分别有55.4%和46.4%为NoV GI和NoV GII。补充维生素A降低了NoV- GII感染的发生率（RR， 0.60[95%可信区间{CI}， 0.20-0.82]），增加了NoV- GI和GII脱落的长度，降低了NoV- GI相关腹泻的发生率（RR, 0.51 [95% CI, 0.26 - 0.97]）。这些发现表明，在本研究人群中，NoV是儿童腹泻的一个重要原因，补充维生素A对NoV感染的具体结果有不同的影响。
Background. The effect of vitamin A supplementation on viral gastrointestinal infections among young children living in developing countries remains unclear.Methods. The effect of vitamin A supplementation on norovirus (NoV) infection among 127 Mexican children 5-15 months of age was studied in a randomized, placebo-controlled trial during June-August 1998. Stool samples collected every 2 weeks and after diarrheal episodes were screened for NoV and characterized at the genogroup level (GI and GII).Results. Of the stool samples collected, 29.9% were positive for NoV, and NoV GI and NoV GII were found in 55.4% and 46.4% of the positive samples, respectively. Vitamin A supplementation reduced the prevalence of NoV GII infections ( rate ratio [RR], 0.60 [95% confidence interval {CI}, 0.20-0.82]), increased the length of both NoV GI and GII shedding, and decreased the prevalence of NoV- associated diarrhea ( RR, 0.51 [ 95% CI, 0.26 0.97]).Conclusions. These findings suggest that NoV is an important cause of pediatric diarrhea in this study population and that vitamin A supplementation has divergent effects on specific outcomes of NoV infection.