PTSD contributes to teen and young adult cannabis use disorders
PTSD contributes to teen and young adult cannabis use disorders
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DOI：
10.1016/j.addbeh.2009.09.007
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发表时间：
2010-02-01
影响因子：
4.4
通讯作者：
Tarter, Ralph
中科院分区：
文献类型：
--
作者：
Cornelius, Jack R.;Kirisci, Levent;Tarter, Ralph
背景：之前涉及成年人的研究表明，创伤后应激障碍（PTSD）会增加大麻使用障碍（CUD）（大麻依赖和大麻滥用）的患病率。然而，尽管 CUD 通常在青春期发病，但针对 PTSD 和 CUD 的研究很少涉及青少年。本研究探讨了 PTSD 对过渡到成年早期的青少年 CUD 的影响。 方法：这项正在进行的研究的受试者是终生有物质使用障碍 (SUD) 史的成年男性（SUD + 先证者，N = 343）与没有 SUD 终生史的成年男性（SUD 先证者，N = 350）。参与者最初是在这些父亲的索引儿子10-12岁时招募的，随后的评估在12-14岁时进行。 16、19、22 和 25。检查的其他变量是与未来发生 SLID 的风险相关的行为控制不足指数，称为传染性责任指数 (TU)，以及与异常同伴的关系。进行多变量逻辑回归和通径分析。结果：在这 693 名受试者中，31 名受试者被诊断患有 PTSD，161 名受试者被诊断患有 CUD。 CUD 受试者包括 136 名男性参与者和 25 名女性参与者，其中包括 103 名（64%）白人参与者和 58 名（36%）其他种族参与者。 Logistic 回归表明，CUD 的发展与同龄人 (Wald = 63.4，p = 0.000)、TU (Wald = 28.8，p = 0.000)、非裔美国人种族 (Wald = 14.2。p = 0.000) 的偏差有关。 PTSD（Wald = 12.7，p = 0.000）、男性（Wald = 12.0，p = 0.001）、家庭社会经济地位（Wald = 9.2。p = 0.002），并且是 SUD + 先证者的后代（Wald = 6.9，p = 0.009）。路径分析表明，PTSD 与 CUD 的存在和同伴偏差直接相关，较高的同伴偏差与 CUD 的存在相关，并且 PTSD 介导了同伴偏差和 CUD 之间的关联。 结论：这些研究结果表明，PTSD 有助于青少年中 CUD 的病因学，使青少年过渡到青年期，超越偏差同龄人的影响，TLI（传染性责任指数，衡量青少年风险的指标） SUD）和人口因素。 (C) 2009 Elsevier Ltd. 保留所有权利。
Background: Previous studies involving adults suggest that Post Traumatic Stress Disorder (PTSD) increases the prevalence of cannabis use disorders (CUD) (cannabis dependence and cannabis abuse). However, little work with PTSD and CUD has been conducted involving adolescents, despite the fact that CUD typically have their onset during adolescence. This study addresses the effect of PTSD on CUD among teenagers transitioning to young adulthood.Method: The subjects in this ongoing study were the offspring of adult men with a lifetime history of a substance use disorder (SUD) (SUD + probands, N = 343) vs those with no lifetime history of a SUD (SUD-probands, N = 350). The participants were initially recruited when the index sons of these fathers were 10-12 years of age, and subsequent assessments were conducted at age 12-14. 16. 19, 22, and 25. Other variables examined were an index of behavioral undercontrol associated with future risk for developing SLID, known as the Transmissible Liability Index, or TU, and affiliation with deviant peers. Multivariate logistic regression and path analyses were conducted.Results: Of these 693 subjects, 31 subjects were diagnosed with PTSD, and 161 were diagnosed with a CUD. The CUD subjects included 136 male participants and 25 female participants, including 103 (64%) Caucasian participants and 58 (36%) participants of other races. Logistic regression demonstrated that the development of a CUD was associated with deviance of peers (Wald = 63.4, p = 0.000), the TU (Wald = 28.8, p = 0.000), African American race (Wald = 14.2. p = 0.000). PTSD (Wald = 12.7, p = 0.000), male gender (Wald = 12.0, p = 0.001), household SES (Wald = 9.2. p = 0.002), and being an offspring of a SUD + proband (Wald = 6.9, p = 0.009). Path analyses demonstrated that PTSD is directly associated with the presence of a CUD and with peer deviance, that higher peer deviance is associated with the presence of a CUD, and that PTSD mediated the association between peer deviance and CUD.Conclusions: These findings suggest that PTSD contributes to the etiology of CUD among teenagers making the transition to young adulthood beyond the effects of deviant peers, the TLI (Transmissible Liability Index, a measure of risk for SUD), and demographic factors. (C) 2009 Elsevier Ltd. All rights reserved.