ENDOTHELIN INDUCTION OF ADHESION MOLECULE EXPRESSION ON HUMAN BRAIN MICROVASCULAR ENDOTHELIAL-CELLS
ENDOTHELIN INDUCTION OF ADHESION MOLECULE EXPRESSION ON HUMAN BRAIN MICROVASCULAR ENDOTHELIAL-CELLS
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DOI：
10.1016/0304-3940(93)90432-k
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发表时间：
1993-06-25
影响因子：
2.5
通讯作者：
SPATZ, M
中科院分区：
文献类型：
--
作者：
MCCARRON, RM;WANG, L;SPATZ, M
循环白细胞与血管内皮的粘附是其迁移到血管外组织的先决条件。本实验表明，细胞间粘附分子-1 （ICAM-1）和血管细胞粘附分子-1 （VCAM-1）在来源于人脑的脑血管内皮细胞系上组成性表达，并且这些分子的表达可被内皮素（ET-1、ET-2和ET-3）以剂量和时间依赖性的方式上调。这些数据还表明ET-1处理诱导了e -选择素在这些细胞上的表达。这些发现暗示血管活性肽参与了炎症部位血细胞的募集。
The adhesion of circulating leukocytes to vascular endothelium is a prerequisite for their emigration to extravascular tissues. The experiments presented here demonstrate that intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are constitutively expressed on cerebromicrovascular endothelial cell lines derived from human brain and that the expression of these molecules can be up-regulated by endothelins (ET-1, ET-2 and ET-3) in a dose- and time-dependent manner. The data also indicate that ET-1 treatment induced the expression of E-selectin on these cells. These findings implicate vasoactive peptides in the recruitment of blood cells at sites of inflammation.