Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment.
Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment.
复制标题
DOI：
10.1155/2016/6058147
复制
发表时间：
2016
影响因子：
4.6
通讯作者：
Bae JS
中科院分区：
文献类型：
--
作者：
Kim J;Bae JS
不同的肿瘤微环境在癌症的每个进展阶段形成，并具有不同的能力，诱导肿瘤发生的不利和有利的后果。现在我们知道免疫细胞可以被激活以促进肿瘤的生长和进展，这很可能受到肿瘤微环境的影响。肿瘤相关巨噬细胞和肿瘤相关中性粒细胞可以发挥肿瘤原功能，增强肿瘤细胞的侵袭转移、血管生成和细胞外基质重塑，同时抑制抗肿瘤免疫监测。考虑到炎症环境中的中性粒细胞招募巨噬细胞，而被招募的巨噬细胞又影响中性粒细胞的功能，肿瘤相关巨噬细胞和肿瘤相关中性粒细胞之间可能存在不同程度的相互作用。血小板还在肿瘤组织中单核细胞和粒细胞的募集和调节中发挥重要作用，提示血小板功能可能对肿瘤相关巨噬细胞和肿瘤相关中性粒细胞的产生至关重要。在这篇综述中，我们将探讨肿瘤相关巨噬细胞和肿瘤相关中性粒细胞的生物学及其在肿瘤微环境中可能的相互作用。将特别关注这些肿瘤相关细胞的募集和激活，以及它们在维持肿瘤微环境和肿瘤进展中所起的作用。
Distinct tumor microenvironment forms in each progression step of cancer and has diverse capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now known that immune cells can be activated to favor tumor growth and progression, most probably influenced by the tumor microenvironment. Tumor-associated macrophages and tumor-associated neutrophils can exert protumoral functions, enhancing tumor cell invasion and metastasis, angiogenesis, and extracellular matrix remodeling, while inhibiting the antitumoral immune surveillance. Considering that neutrophils in inflammatory environments recruit macrophages and that recruited macrophages affect neutrophil functions, there may be various degrees of interaction between tumor-associated macrophages and tumor-associated neutrophils. Platelets also play an important role in the recruitment and regulation of monocytic and granulocytic cells in the tumor tissues, suggesting that platelet function may be essential for generation of tumor-associated macrophages and tumor-associated neutrophils. In this review, we will explore the biology of tumor-associated macrophages and tumor-associated neutrophils and their possible interactions in the tumor microenvironment. Special attention will be given to the recruitment and activation of these tumor-associated cells and to the roles they play in maintenance of the tumor microenvironment and progression of tumors.