Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma
Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma
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DOI：
10.1183/09031936.03.00085302
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发表时间：
2003-12-01
影响因子：
24.3
通讯作者：
Kubo, K
中科院分区：
文献类型：
--
作者：
Gono, H;Fujimoto, K;Kubo, K
本研究的目的是检查通过高分辨率计算机断层扫描（HRCT）量化的无症状哮喘患者大小气道结构变化与气流阻塞之间的关系。右上叶顶支气管（B1）主干处的支气管壁厚度用于评估大气道。空气截留，通过平均值的比率进行评价。使用完全呼气时双侧上下肺段与完全吸气时双侧上下肺段的CT测定值（E/I比值）评估小气道。对24例无症状哮喘患者进行螺旋HRCT测量，随后进行吸入和/或口服皮质类固醇的最佳治疗>6个月。在HRCT检查前（20-30分钟），所有患者均吸入支气管扩张剂。对于14名伴有可逆性气流阻塞不足的哮喘患者，B1支气管的气道壁厚与外径之比（T/D）、壁面积百分比（WA%）和E/I比显着更大（一秒用力呼气量（FEV 1））
The aim of this study was to examine the relationship between the structural changes in large and small airways in asymptomatic asthmatics quantified by high-resolution computed tomography (HRCT) and airflow obstruction. The bronchial wall thickness at the trunk of the apical bronchus (B1) of the right upper lobe was used for assessment of the large airways. Air trapping, evaluated by the ratio of the average. CT-determined values for the bilateral upper and lower lung segments at full expiration to that at full inspiration (E/I ratio), was used for assessment of the small airways. Measurements were obtained with a helical HRCT in 24 asymptomatic asthmatics followed by optimal treatment with inhaled and/or oral corticosteroids for >6 months. Prior (20-30 min) to the HRCT examination, all patients were given an inhaled bronchodilator. The ratio of airway wall thickness to outer diameter (T/D) and the percentage wall area (WA%) at the B1 bronchus and the E/I ratio were significantly greater for the 14 asthmatics with deficient reversible airflow obstruction (forced expiratory volume in one second (FEV1)