Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with 82Rb Dynamic PET
Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with 82Rb Dynamic PET
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DOI：
10.2967/jnumed.108.055673
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发表时间：
2009-01-01
影响因子：
9.3
通讯作者：
Tamaki, Nagara
中科院分区：
文献类型：
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作者：
Manabe, Osamu;Yoshinaga, Keiichiro;Tamaki, Nagara
尚未评价使用Rb-82 PET测量静息和充血心肌血流量（MBF）的可重复性。本研究的目的是调查这种测量的短期可重复性。方法：15名健康志愿者接受静息和药物应激Rb-82 PET，间隔60 min重复。结果如下：重复静息MBF无显著性差异（0.77 +/- 0.25 vs. 0.82 +/- 0.25 mL/min/g，P = 0.31;平均差异，6.18% +/- 12.22%）或反复充血MBF（3.35 +/- 1.37 vs. 3.39 +/- 1.37 mL/min/g，P = 0.81;平均差异，1.17% +/- 13.64%）。静息MBF和充血MBF的重复性系数分别为0.19 mL/min/g和0.92 mL/min/g。结论：采用同一天短期重复性方案，使用Rb-82的MBF具有高度重现性。用Rb-82 PET进行的连续MBF测量应该能够量化治疗干预对MBF的急性影响。
The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using Rb-82 PET has not been evaluated. The aim of this study was to investigate the short-term repeatability of such measurements. Methods: Fifteen healthy volunteers underwent rest and pharmacologic stress Rb-82 PET, repeated 60 min apart. Results: There was no significant difference in repeated rest MBF (0.77 +/- 0.25 vs. 0.82 +/- 0.25 mL/min/g, P = 0.31; mean difference, 6.18% +/- 12.22%) or repeated hyperemic MBF (3.35 +/- 1.37 vs. 3.39 +/- 1.37 mL/min/g, P = 0.81; mean difference, 1.17% +/- 13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. Conclusion: MBF using Rb-82 is highly reproducible using a same-day short-term repeatability protocol. Serial MBF measurements with Rb-82 PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.