Artificial metalloenzymes: The powerful alliance between protein scaffolds and organometallic catalysts
Artificial metalloenzymes: The powerful alliance between protein scaffolds and organometallic catalysts
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DOI：
10.1016/j.cogsc.2020.100420
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发表时间：
2021-01-01
影响因子：
9.3
通讯作者：
Duhme-Klair, Anne-Kathrin
中科院分区：
文献类型：
--
作者：
Large, Benjamin;Baranska, Natalia G.;Duhme-Klair, Anne-Kathrin
近年来，人工金属酶的发展取得了长足的进步。通过定点突变、定点饱和突变和定向进化等技术，这些复合生物无机催化剂的选择性得到了提高。通过引入各种非生物金属催化剂、开发新的锚定策略和新的设计以通过构思模块化和可逆组件来增强其可重用性，它们的范围得到了扩大。本综述重点介绍了在过去两年中取得的最重要的进展及其对更可持续的化学发展的贡献。
In recent years, substantial advances have been made in the development of artificial metalloenzymes. These hybrid bio-inorganic catalysts have seen their selectivity improved through techniques including site-directed and site-saturation mutagenesis and directed evolution. Their scope has been expanded by the introduction of various abiological metal catalysts, the development of new anchoring strategies and new designs to enhance their reusability by conceiving modular and reversible assemblies. This review highlights a selection of the most significant advances made in the last 2 years and their contribution to the development of a more sustainable chemistry.