EFFECT OF SOME ANTIESTROGENS AND AROMATASE INHIBITORS ON ANDROGEN INDUCED SEXUAL-BEHAVIOR IN CASTRATED MALE RATS
EFFECT OF SOME ANTIESTROGENS AND AROMATASE INHIBITORS ON ANDROGEN INDUCED SEXUAL-BEHAVIOR IN CASTRATED MALE RATS
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DOI：
10.1016/0018-506x(76)90040-4
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发表时间：
1976-01-01
影响因子：
3.5
通讯作者：
PEREZPALACIOS, G
中科院分区：
文献类型：
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作者：
BEYER, C;MORALI, G;PEREZPALACIOS, G
抗雌激素（MER-25 [ethamoxytriphetol]、ICI-46474 [他莫昔芬]和顺式-克罗米芬）和芳香酶抑制剂（5-α-雄烷二酮、甲氧匹隆和氨基-谷氨酰亚胺）对雄激素诱导的交配行为的影响。每天注射1毫克睾酮（T），持续21天，在大多数受试者中诱导了性活动（61%安装）。每日给予MER-25或顺式克罗米酚3个剂量水平的预处理均不能阻断T. ICI-46474在高剂量水平（1 mg/kg）下对T处理的去势大鼠的性行为引起显著的抑制作用。单次注射6 mg丙酸睾丸酮（TP）可在120 h内诱导56%的实验大鼠出现爬马行为。用美托吡酮或5 α-雄甾烷二酮（每12小时注射一次，共96小时）不抑制对TP的反应。与此相反，氨鲁米特（5或15毫克，每12小时，96小时）取消雄激素的行为反应。
The effect of antiestrogens (MER-25 [ethamoxytriphetol], ICI-46474 [tamoxifen] and cis-clomiphene) and aromatase inhibitors (5-.alpha.-androstanedione, metopirone, and amino-glutethimide) on androgen induced copulatory behavior was tested in sexually inexperienced castrated male rats. Daily injections of 1 mg testosterone (T) for 21 days induced sexual activity in most subjects (61% mounting). Daily pretreatment with MER-25 or cis-clomiphene at 3 dose levels did not block the behavioral response to T. ICI-46474 at the high dose level (1 mg/kg) elicited a significant depressory effect on the sexual behavior of the T treated castrated rats. A single injection of 6 mg testosterone propionate (TP) induced mounting behavior in 56% of the tested rats within 120 h. Treatment with metopirone or 5 .alpha.-androstanedione (injections every 12 h for 96 h) did not inhibit the response to TP. By contrast, aminoglutethimide (5 or 15 mg every 12 h for 96 h) abolished the behavioral response to androgen.