Nutritional Status of Adult Patients with Pulmonary Tuberculosis in Rural Central India and Its Association with Mortality
Nutritional Status of Adult Patients with Pulmonary Tuberculosis in Rural Central India and Its Association with Mortality
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DOI：
10.1371/journal.pone.0077979
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发表时间：
2013-10-24
期刊：
影响因子：
3.7
通讯作者：
Menzies, Dick
中科院分区：
文献类型：
--
作者：
Bhargava, Anurag;Chatterjee, Madhuri;Menzies, Dick
营养不良是结核病的一个已知危险因素，会对治疗结果产生不利影响。然而，尽管印度结核病负担沉重且营养不良，但来自印度的数据却很少。我们评估了 2004 年至 2009 年印度农村地区 1695 名成年肺结核患者的连续队列中诊断和完成治疗时的营养状况及其与结核病治疗期间死亡的关联。使用多变量逻辑回归来获得营养状况与治疗期间死亡关联的调整估计值。诊断时，男性BMI和体重中位数分别为16.0 kg/m(2)和42.1 kg，女性为15.0 kg/m(2)和34.1 kg，表明80%的女性和67%的男性存在中度至重度营养不良(BMI)
Under-nutrition is a known risk factor for TB and can adversely affect treatment outcomes. However, data from India are sparse, despite the high burden of TB as well as malnutrition in India. We assessed the nutritional status at the time of diagnosis and completion of therapy, and its association with deaths during TB treatment, in a consecutive cohort of 1695 adult patients with pulmonary tuberculosis in rural India during 2004 - 2009. Multivariable logistic regression was used to obtain adjusted estimates of the association of nutritional status with deaths during treatment. At the time of diagnosis, median BMI and body weights were 16.0 kg/m(2) and 42.1 kg in men, and 15.0 kg/m(2) and 34.1 kg in women, indicating that 80% of women and 67% of men had moderate to severe under-nutrition (BMI