Key Principles of Antiretroviral Pharmacology
Key Principles of Antiretroviral Pharmacology
复制标题
DOI：
10.1016/j.idc.2019.05.006
复制
发表时间：
2019-09-01
影响因子：
4.4
通讯作者：
Dionne, Brandon
中科院分区：
文献类型：
--
作者：
Dionne, Brandon
自齐多夫定首次获得批准以来，抗逆转录病毒治疗取得了显著进展。尽管FDA已经批准了31种抗逆转录病毒药物，但其中只有大约一半是常用的。更新、更耐受的药物已经使人类免疫缺陷病毒成为一种慢性疾病，可以通过药物治疗。最常见的抗逆转录病毒方案包括两种核苷逆转录酶抑制剂和第三种药物，通常是整合酶抑制剂，因为与其他方案相比，耐受性更好，药物相互作用更少。了解抗逆转录病毒药物的剂型、不良反应和药物相互作用使临床医生能够为他们的患者选择最合适的方案。新的发展，如品牌仿制疗法和长效肌肉注射，可能在未来发挥更大的作用。
Antiretroviral therapy has advanced significantly since zidovudine was first approved. Although 31 antiretrovirals have been approved by the FDA, only about half of those are commonly used. Newer, more tolerable agents have made human immunodeficiency virus into a chronic condition, which can be managed with medication. The most common antiretroviral regimens consist of 2 nucleoside reverse transcriptase inhibitors plus a third agent, often an integrase inhibitor because of better tolerability and fewer drug interactions than other regimens. Understanding the dosage forms, adverse effects, and drug interactions of antiretrovirals allow clinicians to choose the most appropriate regimen for their patient. New developments, such as branded generic regimens and long-acting intramuscular injections, may play a larger role in the future.