Neural origins of the P300.
Neural origins of the P300.
复制标题
DOI：
10.1615/critrevneurobiol.v14.i3-4.20
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
M. Soltani;Robert T. Knight
中科院分区：
文献类型：
--
作者：
M. Soltani;Robert T. Knight
回顾人类探测行为的神经起源研究发现，事件相关电位P3a和P3b各自具有不同的神经组织和认知功能。P3a参与自动新奇探测，其特点是更前部的皮质分布，而P3b与意志性目标探测有关，更后部的皮质分布。颅内调查、对脑局灶性病变患者的研究以及功能神经成像(FMRI)研究与头皮记录的事件相关电位(ERP)数据融合在一起，表明广泛的皮质网络导致了自动和控制的检测行为。一直被认为产生与检测相关的大脑激活的主要区域包括颞顶交界处、内侧颞叶复合体和外侧前额叶皮质。现有的人类和动物文献涉及神经网络、神经药理学基础和P300电位的行为意义，将被复习。
A review of the literature investigating the neural origins of detection behavior in humans reveals two event-related potential components, P3a and P3b, each with a distinct neural organization and cognitive function.The P3a is involved in automatic novelty detection and characterized by a more anterior cortical distribution, whereas the P3b is concerned with volitional target detection and has a more posterior cortical distribution. Intracranial investigation, studies with patients with focal brain lesions, and functional neuroimaging (fMRI) studies converge with scalp-recorded event-related potential (ERP) data in suggesting that a widespread cortical network gives rise to both automatic and controlled detection behavior. The main regions consistently attributed to generating detection-related brain activation include the temporal-parietal junction, medial temporal complex, and the lateral prefrontal cortex. The extant human and animal literature addressing the neural networks, neuropharmacological underpinnings, and behavioral significance of the P300 potential will be reviewed.