Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus
Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus
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DOI：
10.1248/bpb.30.795
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发表时间：
2007-04-01
影响因子：
2
通讯作者：
Kim, Won-Gon
中科院分区：
文献类型：
--
作者：
Lee, Jong-Gyo;Yoo, Ick-Dong;Kim, Won-Gon
来源于亚硝基芽孢链霉菌的3-氯-四氢喹诺酮类生物碱苯司他汀C对1型单纯疱疹病毒（HSV-1）、2型单纯疱疹病毒（HSV- 2）和水疱性口炎病毒（VSV）的EC50分别为1.92、0.53和1.99 μ g/ml，呈剂量依赖性。相比之下，苯他汀D，相应的脱氯衍生物，没有表现出任何抗病毒活性。这些结果表明，苯司他汀C的抗病毒活性部分是由其分子结构中的氯部分介导的。
Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC50, values of 1.92, 0.53, and 1.99 mu g/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV 2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.