Biodistribution and acute toxicity of intravenous multifunctional 125I-radiolabeled Fe3O4-Ag heterodimer nanoparticles in mice.
Biodistribution and acute toxicity of intravenous multifunctional 125I-radiolabeled Fe3O4-Ag heterodimer nanoparticles in mice.
复制标题
静脉内多功能 125I 放射性标记 Fe3O4-Ag 异二聚体纳米粒子在小鼠体内的生物分布和急性毒性。
DOI：
10.1155/2018/3150351
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发表时间：
2018
影响因子：
--
通讯作者：
Deng Shengming
中科院分区：
文献类型：
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作者：
Zhang Bin;Zhu Jing;Gu Hongwei;Deng Shengming
Fe3O4‐Ag125I异质结构放射性核素纳米颗粒（NPs）已被开发为一种新型的双模成像剂，用于单光子发射计算机断层扫描（SPECT）和磁共振成像（MRI）。然而，Fe3O4‐Ag125I NPs的生物分布和毒性在很大程度上仍然未知。因此，我们通过急性毒性实验（暴露超过7天）研究了Fe3O4‐Ag125I NPs在小鼠体内的生物分布和生物作用。通过体内实验研究了Fe3O4 - Ag125I NPs的生物积累。分析血清生化和血液学以揭示潜在的功能变化。电镜下观察组织病理变化。生物分布分析表明，Fe3O4‐Ag125I NPs主要积聚在肝脏和脾脏。与对照组相比，Fe3O4‐Ag125I NP刺激组肝酶（ALT和AST）活性升高。总的来说，肝脏和脾脏是Fe3O4‐Ag125I NPs积累的主要靶器官。与对照组相比，Fe3O4‐Ag125I NP刺激组观察到肝组织损伤。进一步研究靶材料在Fe3O4‐Ag表面的涂层对于Fe3O4‐AgNPs作为双模成像剂的安全医疗应用是非常必要的。
Fe3O4‐Ag125I heterostructured radionuclide nanoparticles (NPs) have been developed as a novel type of dual‐modality imaging agents for single‐photon emission computerized tomography (SPECT) and magnetic resonance imaging (MRI). However, the biodistribution and toxicity of Fe3O4‐Ag125I NPs remain largely unknown. Therefore, we investigated the biodistribution and biological action of Fe3O4‐Ag125I NPs in mice by acute toxicity experiments (exposures over 7 days). The bioaccumulation of Fe3O4‐Ag125I NPs was studied viain vivoexperiments. The serum biochemistry and hematology were analyzed to reveal potential functional changes. The histopathological changes were observed by using an electron microscope. Biodistribution analysis revealed that Fe3O4‐Ag125I NPs were mainly accumulated in the liver and spleen. The activities of liver enzymes (ALT and AST) were increased in Fe3O4‐Ag125I NP‐challenged groups compared with the control groups. Collectively, liver and spleen were the major target organs for accumulation of Fe3O4‐Ag125I NPs. Damage of liver tissue was observed in the Fe3O4‐Ag125I NP‐challenged groups compared with the control groups. Further studies on surface coating of Fe3O4‐Ag with targeted materials are highly necessary for safe medical applications of Fe3O4‐AgNPs as dual‐modality imaging agents.