INTERICTAL SPIKING INCREASES AFTER SEIZURES BUT DOES NOT AFTER DECREASE IN MEDICATION
INTERICTAL SPIKING INCREASES AFTER SEIZURES BUT DOES NOT AFTER DECREASE IN MEDICATION
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DOI：
10.1016/0013-4694(89)90026-6
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
KOFFLER, DJ
中科院分区：
文献类型：
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作者：
GOTMAN, J;KOFFLER, DJ
在局灶性癫痫患者中，EEG棘波率随时间波动很大。我们以前已经表明，癫痫发作的发生在这些波动中发挥了重要作用。我们进行了这项研究，以证实这一发现，更好地控制关键变量，如警觉状态和尖峰量化，并评估变化的空间范围。还检查了与加标相关的背景活动变化和抗癫痫药物水平。在癫痫发作后的数小时和数天内，广泛脑区（包括但不限于癫痫发作病灶）的棘波放电率增加。癫痫发作前峰电位率没有系统性变化。背景活动的爆发后变化并不平行尖峰波动。抗癫痫药物水平降低不会导致尖峰频率增加。这些结果表明，癫痫发作后，有激活的发作间期尖峰，这是不是由背景活动的变化所掩盖。最常见的是广泛分布，不一定在癫痫发作部位最突出。
In patients with focal epilespy, EEG spike rate fluctuates considerably over time. We had previously shown that seizure occurrence played an important role in these fluctuations. We undertook this study to confirm this finding with better control of critical variables such as state of alertness and spike quantification, and to assess the spatial extent of the changes. Background activity changes and antiepileptic drug levels were also examined in relation to spiking. Spike discharge rate increased in the hours and days following seizures in widespread brain regions including, but not restricted to, the seizure focus. Spike rate did not change systematically before seizures. Postictal changes in background activity did not parallel spike fluctuations. Decreased antiepileptic drug levels did not cause increased spike rate. These results indicate that, following seizures, there is activation of interictal spiking which is not paralleled by changes in background activity. It is most often widespread and not necessarily most prominent at the site of seizure onset.