Degradation of AFB1 in aqueous medium by electron beam irradiation: Kinetics, pathway and toxicology
Degradation of AFB1 in aqueous medium by electron beam irradiation: Kinetics, pathway and toxicology
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电子束照射在水介质中降解 AFB1：动力学、途径和毒理学
DOI：
10.1016/j.foodcont.2016.02.002
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发表时间：
2016-08-01
期刊：
影响因子：
6
通讯作者：
Wang, Xingguo
中科院分区：
文献类型：
--
作者：
Liu, Ruijie;Wang, Ruiqi;Wang, Xingguo
采用不同初始浓度的电子束辐照（EBI）对黄曲霉毒素B-1 （AFB(1)）在水溶液中的降解进行了研究。已经证明，在选定的浓度范围内，AFB1的降解符合准一级反应动力学（R-2 > 0.95）。采用UPLC-Q-TOF/MS对水溶液中AFB(1)的5种降解产物进行了鉴定，并提出了可能的降解途径。采用Ames和细胞毒性试验评价了AFB(1)降解产物在水溶液中的毒性，结果表明，EBI处理后的样品的致突变性和细胞毒性较未处理的样品明显降低，但未完全消失。该研究为EBI方法在AFB(1)去污中的应用提供了线索。(C) 2016 Elsevier Ltd.版权所有。
The degradation study of aflatoxin B-1 (AFB(1)) in aqueous medium was performed under electron beam irradiation (EBI) at various AFB(1) initial concentrations. It has been proven that the degradation of AFB1 in the selected ranges of concentrations follows pseudo first-order reaction kinetics well (R-2 > 0.95). Five degradation products of AFB(1) in aqueous solution were identified by UPLC-Q-TOF/MS, and the possible degradation pathway was proposed. The Ames and cytotoxicity tests were employed to evaluate the toxicity of the AFB(1) degradation products in aqueous solution, and the results indicated that the mutagenicity and cytotoxicity of EBI treated samples decreased significantly compared with that of untreated samples, but were not completely disappeared. The study provided clues involving the application of EBI methods in AFB(1) decontamination. (C) 2016 Elsevier Ltd. All rights reserved.