Parameters of ovarian reserve in relation to urinary concentrations of parabens
Parameters of ovarian reserve in relation to urinary concentrations of parabens
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DOI：
10.1186/s12940-020-00580-3
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发表时间：
2020-03-02
影响因子：
6
通讯作者：
Hanke, Wojciech
中科院分区：
文献类型：
--
作者：
Jurewicz, Joanna;Radwan, Michal;Hanke, Wojciech
对羟基苯甲酸酯是一种合成化学物质，通常用作化妆品、药品、食品和饮料加工中的抗菌防腐剂。在实验动物中，对羟基苯甲酸酯暴露与雌性生殖的不利影响有关。尽管对羟基苯甲酸酯广泛使用，但人们对其对女性生育能力的影响知之甚少。当前分析的目的是评估在生育诊所接受治疗的妇女尿液对羟基苯甲酸酯浓度与卵巢储备参数的关系。方法2014年9月至2019年2月期间，在波兰中部地区不孕症诊所就诊的511名25-39岁女性进行诊断。尿中对羟基苯甲酸酯的浓度采用气相色谱-离子束质谱法测定。卵巢储备指标：窦卵泡计数（AFC）、抗苗勒管激素（AMH）、促卵泡激素（FSH）、雌二醇（E-2）水平。结果尿中甲基（MP）、乙基（EP）、丙基（PP）、丁基（BP）、对羟基苯甲酸异丁酯（iBuP）比重调节浓度几何平均值分别为107.93、12.9、18.67、5.02、2.80 μ g/L。暴露的第三个四分位数的尿液PP浓度（（50-75）百分比）与窦卵泡计数（p = 0.048）、雌二醇水平（p = 0.03）呈负相关，与FSH浓度呈正相关（p = 0.026）。MP、EP、BP和iBuP与卵巢储备参数无相关性。结论长期暴露于PP可能导致生殖力降低和生育能力受损。由于本研究是首次探讨对羟基苯甲酸酯对卵巢储备的潜在影响的研究之一，需要进一步的流行病学研究和更长的观察时间。
Background Parabens are synthetic chemicals commonly used in cosmetics, pharmaceuticals, food and beverage processing as antimicrobial preservatives. In experimental animals, parabens exposure was associated with adverse effects on female reproduction. Despite the widespread use of parabens little is known about their effect on female fecundity. The objective of the current analysis was to evaluate the associations of urinary parabens concentrations with parameters of ovarian reserve among women undergoing treatment in a fertility clinic. Methods Five hundred eleven female aged 25-39 years who attended the infertility clinic in central region of Poland for diagnostic purposes were recruited between September 2014 and February 2019. Urinary concentrations of parabens were measured by a validated gas chromatograohy ion-tap mass spectrometry method. Parameters of ovarian reserve were: antral follicle count (AFC), anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH) and estradiol (E-2) levels. Results The geometric mean of specific gravity adjusted urinary concentrations of methyl (MP), ethyl (EP), propyl (PP), butyl (BP) and izobutyl paraben (iBuP) were 107.93 mu g/L, 12.9 mu g/L, 18.67 mu g/L, 5.02 mu g/L and 2.80 mu g/L. Urinary concentrations of PP in the third quartile of exposure ((50-75] percentyl) were inversely associated with antral follicle count (p = 0.048), estradiol level (p = 0.03) and positively with FSH concentration (p = 0.026). MP, EP, BP and iBuP parabens were not associated any with parameters of ovarian reserve. Conclusions Chronic exposure to PP may potentially contributing to reduced fecundity and impair fertility. As this is one of the first study to investigate the potential effect of parabens on ovarian reserve further epidemiological studies with longer duration of observation are needed.