EVIDENCE THAT D-FENFLURAMINE ANOREXIA IS MEDIATED BY 5-HT1 RECEPTORS
EVIDENCE THAT D-FENFLURAMINE ANOREXIA IS MEDIATED BY 5-HT1 RECEPTORS
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DOI：
10.1007/bf00442252
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发表时间：
1989-01-01
影响因子：
3.4
通讯作者：
COOPER, SJ
中科院分区：
文献类型：
--
作者：
NEILL, JC;COOPER, SJ
The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine''s effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by the 5-HT2 receptor antagonist ritanserin; and by (.+-.)cyanopindolol, a mixed 5-HT1A/5-HT1B receptor antagonist. In contrast, d-fenfluramine''s effect was not antagonised by the 5-HT2 receptor antagonists ketanserin and ICI 169 369; the 5-HT3 receptor antagonist ICS 205 930; or by xylamidine, a peripheral 5-HT receptor antagonist. In this feeding model, none of the 5-HT antagonists, when tested alone, had any effect to increase palatable food consumption. The pattern of results obtained strongly suggest that central 5-HT1 receptors play an important role in the mediation of d-fenfluramine-induced anorexia.
