Effects of GABAA receptor antagonism on inspiratory activities in kittens.
Effects of GABAA receptor antagonism on inspiratory activities in kittens.
复制标题
GABAA 受体拮抗作用对小猫吸气活动的影响。
DOI：
10.1016/0304-3940(93)90400-f
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发表时间：
1993
影响因子：
2.5
通讯作者：
Steele,AM
中科院分区：
文献类型：
--
作者：
Sica,AL;Siddiqi,ZA;Hundley,BW;Gootman,PM;Steele,AM
在麻醉小猫（<1至24日龄）中，通过静脉输注荷包牡丹碱，在高氧和缺氧期间检查GABA A受体拮抗剂对膈、舌下和颈交感神经放电的影响。在高氧期间给予荷包牡丹碱可使吸气神经放电幅度显著增加。在低氧刺激（10%O2），吸气活动的幅度下降到或低于高氧期间观察到的;荷包牡丹碱扭转这种抑郁症，恢复吸气放电。我们的研究结果表明，GABAA受体出生后不久就发挥作用，在高氧呼吸和化学驱动增加的条件下，调节影响吸气活动的形成。
In anesthetized kittens (<1 to 24 days old), the effects of GABAAreceptor antagonism on phrenic, hypoglossal and cervical sympathetic discharges were examined by i.v. bicuculline infusions during hyperoxia and hypoxia. Administration of bicuculline during hyperoxia produced marked increases in the amplitudes of inspiratory nerve discharges. During hypoxic stimulation (10% O2), the amplitudes of inspiratory activities decreased towards or below those observed during hyperoxia; bicuculline reversed this depression and restored inspiratory discharges. Our results indicated that GABAAreceptors were functional shortly after birth, acting to mediate influences shaping inspiratory activity during hyperoxic breathing and during conditions of increased chemical drive.