REGIONAL CEREBRAL BLOOD-FLOW RESPONSE DURING AND AFTER ACUTE ASPHYXIA IN NEWBORN PIGLETS
REGIONAL CEREBRAL BLOOD-FLOW RESPONSE DURING AND AFTER ACUTE ASPHYXIA IN NEWBORN PIGLETS
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DOI：
10.1152/jappl.1989.66.6.2827
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发表时间：
1989-06-01
影响因子：
3.3
通讯作者：
DELIVORIAPAPADOPOULOS, M
中科院分区：
文献类型：
--
作者：
GOPLERUD, JM;WAGERLE, LC;DELIVORIAPAPADOPOULOS, M
研究了 14 只新生仔猪急性窒息期间和之后的血流动力学反应。通过停止通气直至仔猪出现心动过缓（心率 < 80 次/分钟），对瘫痪的机械通气仔猪产生类似呼吸暂停的窒息损伤。在对照组、窒息期间（PO2 = 16 .+-. 11 Torr，pH = 7.31 .+-. 0.07，PCO2 = 47 .+-. 9 Torr）和从窒息恢复期间，对七只仔猪进行了器官血流量测量。急性窒息期间，器官血流发生快速重新分配，导致肾脏和骨骼肌血流减少，而冠状动脉血流增加。尽管窒息期间脑总血流量变化不大，但局部脑血流量（rCBF）分析显示，窒息期间脑内血流分布显着不均匀，大脑灰质、白质和脉络丛减少，而脑干结构血流增加。在再通气恢复期间，总脑血流量比对照增加了 24%，分布更加均匀，流向所有大脑区域的流量也有所增加。然后通过在窒息 30-60 秒、60-120 秒和 120-180 秒连续进行 CBF 测量，确定急性窒息期间 rCBF 变化的时间过程。在皮质结构中看到的血管收缩，与骨骼和肾脏血流量的减少同时发生，已知是交感神经介导的，表明该大脑区域存在选择性反射效应。窒息期间脑干区域更加渐进和渐进的血管舒张与化学控制一致。这些发现表明新生仔猪 CBF 调节存在显着的区域异质性。
The hemodynamic response during and after acute asphyxia was studied in 14 newborn piglets. An apnea-like asphyxial insult was produced in paralyzed mechanically ventilated piglets by discontinuing ventilation until the piglets became bradycardic (heart rate < 80 beats/min). Seven piglets had organ blood flow measured by microspheres at control, during asphyxia (PO2 = 16 .+-. 11 Torr, pH = 7.31 .+-. 0.07, PCO2 = 47 .+-. 9 Torr), and during recovery from asphyxia. During acute asphyxia, rapid organ blood flow redistribution occurred, producing decreased renal and skelteal muscle blood flow, while coronary blood flow increased. Although total brain blood flow changed little during asphyxia, regional cerebral blood flow (rCBF) analysis revealed significant nonhomogeneous blood flow distribution within the brain during asphyxia, with decreases to the cerebral gray and white matter and the choroid plexus, whereas brain stem structures had increased flow. During recovery with reventilation, total brain blood flow increased 24% above control, with a more uniform distribution and increased flow to all brain regions. The time course of rCBF changes during acute asphyxia was then determined in seven additional niglets with CBF measurements made sequentially at 30-60 s 60-120 s, and 120-180 s of asphyxia. The vasoconstriction seen in cortical structures, concurrent with the reduction in skeletal and kidney blood flow, known to be sympathetically mediated, suggest a selective reflex effect in this brain region. The more gradual and progressive vasodilation in brain stem regions during asphyxia is consistent with chemical control. These findings demonstrate significant regional heterogeneity in CBF regulation in newborn piglets.