Effectiveness and Duration of Protection of a Fourth Dose of Coronavirus Disease 2019 Messenger RNA Vaccine Among Long-term Care Residents in Ontario, Canada
Effectiveness and Duration of Protection of a Fourth Dose of Coronavirus Disease 2019 Messenger RNA Vaccine Among Long-term Care Residents in Ontario, Canada
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DOI：
10.1093/infdis/jiac468
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发表时间：
2022-12-03
影响因子：
6.4
通讯作者：
Kwong, Jeffrey C.
中科院分区：
文献类型：
--
作者：
Grewal, Ramandip;Nguyen, Lena;Kwong, Jeffrey C.
我们估计了加拿大安大略省长期护理居民中第四剂信使RNA冠状病毒病2019疫苗预防Omicron感染的有效性和严重后果。第四剂提供了对与奥美康相关的后果的额外保护，但这种保护随着时间的推移而减弱，与严重后果相比，更多的是针对感染的减弱。
We estimated the effectiveness of a fourth dose of messenger RNA coronavirus disease 2019 vaccine against Omicron infections and severe outcomes over time among long-term care residents in Ontario, Canada. Fourth doses provide additional protection against Omicron-related outcomes, but the protection wanes over time, with more waning seen against infection than severe outcomes.