Effects of methylphenidate on basic and higher-order oculomotor functions
Effects of methylphenidate on basic and higher-order oculomotor functions
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DOI：
10.1177/0269881112446531
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发表时间：
2012-11-01
影响因子：
4.1
通讯作者：
O'Driscoll, Gillian A.
中科院分区：
文献类型：
--
作者：
Allman, Ava-Ann;Ettinger, Ulrich;O'Driscoll, Gillian A.
眼球运动是药物对感觉运动和认知过程影响的敏感指标。哌甲酯（MPH）是精神病学中最常用的处方药之一。它越来越多地被健康个体用作认知增强剂。然而，很少有人知道它对健康认知的影响。在这里，我们使用视力测试来评估MPH对基本视力和执行功能的影响。29名男性在双盲安慰剂对照交叉设计中口服20 mg MPH。胶囊给药后1小时，参与者进行视觉引导扫视、正弦平滑追踪、预测性扫视和反扫视。在胶囊给药前评估心率和血压，并在任务执行前后再次评估。视觉引导扫视潜伏期随着MPH的增加而减少（p
Eye movements are sensitive indicators of pharmacological effects on sensorimotor and cognitive processing. Methylphenidate (MPH) is one of the most prescribed medications in psychiatry. It is increasingly used as a cognitive enhancer by healthy individuals. However, little is known of its effect on healthy cognition. Here we used oculomotor tests to evaluate the effects of MPH on basic oculomotor and executive functions. Twenty-nine males were given 20mg of MPH orally in a double-blind placebo-controlled crossover design. Participants performed visually-guided saccades, sinusoidal smooth pursuit, predictive saccades and antisaccades one hour post-capsule administration. Heart rate and blood pressure were assessed prior to capsule administration, and again before and after task performance. Visually-guided saccade latency decreased with MPH (p