Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats.
Antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Linn.) in streptozotocin-induced diabetic rats.
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DOI：
10.4103/0976-0105.121655
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Vijaya C
中科院分区：
文献类型：
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作者：
Petchi RR;Parasuraman S;Vijaya C
目的：研究原楚梅全株乙醇提取物对链脲佐菌素诱导的糖尿病大鼠的降糖和降血脂作用。在泰米尔纳德邦的马杜赖地区的不同地区采集了整株土豆杉。用乙醇（95%）在索氏装置中风干的原棘全株提取72 h，用链脲佐菌素（50 mg/jk，灌胃）和烟酰胺（120 mg/kg，灌胃）诱导雄性Wistar大鼠糖尿病。提取液的干质量用于初步的植物化学和药理分析。用格列本脲（0.25 mg/kg, p.o.）或原藜提取物（250和500 mg/k， p.o.）连续治疗糖尿病大鼠21 d。定期采集血液样本，以获得整株赤豆的乙醇提取物的降糖效果。实验结束时，分析所有实验动物的血脂和肝酶水平，并与糖尿病对照组进行比较。对原丘茴香全株乙醇提取物进行了初步的植物化学分析，发现其含有生物碱、单宁、黄酮类化合物、皂苷和酚类化合物。250mg /kg和500mg /kg的原棘全株乙醇提取物具有显著的抗糖尿病和降血脂活性。与对照组动物相比，糖尿病对照组动物的体重明显下降。原甘菊抑制链脲佐菌素引起的体重减轻，并显著改变脂质水平。原甘菊全株乙醇提取物对链脲佐菌素诱导的大鼠糖尿病有明显的降糖、降血脂作用。
To study the antidiabetic and antihyperlipidemic effects of an ethanolic extract of the whole plant of Tridax procumbens (Asteraceae) in streptozotocin-induced diabetic rats. The whole plant of T. procumbens was collected in different regions of Madurai districts, Tamil Nadu. The air dried whole plant of T. procumbens was extracted with ethanol (95%) in a Soxhlet apparatus for 72 h. Diabetes was induced in male Wistar rats by streptozotocin (50 mg/jk, i.p.) and nicotinamide (120 mg/kg, i.p) injection. The dry mass of the extract was used for preliminary phytochemical and pharmacological analysis. Diabetic rats were treated with glibenclamide (0.25 mg/kg, p.o.) or T. procumbens extract (250 and 500 mg/k, p.o.) for 21 consecutive days. The blood samples were collected at regular intervals to access hypoglycemic effect of an ethanolic extract of the whole plant of T. procumbens. At the end of the experiment, serum lipid profile and liver enzymes levels were analyzed for all the experimental animals and compared with diabetic control. The preliminary phytochemical analysis of an ethanolic extract of the whole plant of T. procumbens indicated the presence of alkaloids, tannins, flavonoids, saponins, and phenolic compounds. The ethanolic extract of the whole plant of T. procumbens at 250 and 500 mg/kg has significant antidiabetic and antihyperlipidemic activities. The diabetic control animals exhibited a significant decrease in body weight compared with control animals. T. procumbens inhibited streptozotocin-induced weight loss and significantly alter the lipid levels. The ethanolic extract of the whole plant of T. procumbens showed significant antidiabetic and antihyperlipidemic activities against streptozotocin-induced diabetes in rats.