Chronic graft-versus-host disease after granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation: the role of donor T-cell dose and differentiation.
Chronic graft-versus-host disease after granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation: the role of donor T-cell dose and differentiation.
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粒细胞集落刺激因子动员的同种异体干细胞移植后的慢性移植物抗宿主病：供体 T 细胞剂量和分化的作用。
DOI：
10.1016/j.bbmt.2004.02.002
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
G. Hill
中科院分区：
文献类型：
--
作者：
K. Macdonald;Vanessa Rowe;C. Filippich;Diana H. Johnson;E. Morris;A. Clouston;J. Ferrara;G. Hill
The use of granulocyte colony-stimulating factor (G-CSF)–mobilized peripheral blood as a source of stem cells has resulted in a high incidence of severe chronic graft-versus-host disease (cGVHD), which compromises the outcome of clinical allogeneic stem cell transplantation. We have studied the effect of G-CSF on both immune complex and fibrotic cGVHD directed to major (DBA/2 → B6D2F1) or minor (B10.D2 → BALB/c) histocompatibility antigens. In both models, donor pretreatment with G-CSF reduced cGVHD mortality in association with type 2 differentiation. However, after escalation of the donor T-cell dose, scleroderma occurred in 90% of the recipients of grafts from G-CSF-treated donors. In contrast, only 11% of the recipients of control grafts developed scleroderma, and the severity of hepatic cGVHD was also reduced. Mixing studies confirmed that in the presence of high donor T-cell doses, the severity of scleroderma was determined by the non-T-cell fraction of grafts from G-CSF-treated donors. These data confirm that the induction of cGVHD after donor treatment with G-CSF is dependent on the transfer of large numbers of donor T cells in conjunction with a putatively expanded myeloid lineage, providing a further rationale for the limitation of cell dose in allogeneic stem cell transplantation.
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来自 G-CSF 处理的供体的同种异体外周血细胞实验性移植后的长期植入、移植物抗宿主病和免疫重建。
DOI：
--
发表时间：
1996
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
影响因子：
--
作者：
Pan,L;Bressler,S;Cooke,KR;Krenger,W;Karandikar,M;Ferrara,JL
通讯作者：
Ferrara,JL
影响因子：
4.4
作者：
B. Hamilton
通讯作者：
B. Hamilton
抑制 IgE-Fc epsilon RI α 相互作用的肽类似物可改善致命的移植物抗宿主病的发展。
DOI：
--
发表时间：
1997
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
影响因子：
--
作者：
Korngold,R;Jameson,BA;McDonnell,JM;Leighton,C;Sutton,BJ;Gould,HJ;Murphy,GF
通讯作者：
Murphy,GF
影响因子：
20.3
作者：
M. Arpinati;C. Green;S. Heimfeld;Jill E. Heuser;C. Anasetti
通讯作者：
M. Arpinati;C. Green;S. Heimfeld;Jill E. Heuser;C. Anasetti
影响因子：
20.3
作者：
Jinling Liu;Britt E. Anderson;Marie E. Robert;Jennifer M. McNiff;Stephen G. Emerson;W. Shlomchik;Mark Shlomchik
通讯作者：
Jinling Liu;Britt E. Anderson;Marie E. Robert;Jennifer M. McNiff;Stephen G. Emerson;W. Shlomchik;Mark Shlomchik