Paracrine signaling in islet function and survival.
Paracrine signaling in islet function and survival.
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DOI：
10.1007/s00109-020-01887-x
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
Cox AR
中科院分区：
文献类型：
--
作者：
Hartig SM;Cox AR
胰岛是一个密集的细胞网络，由几种类型的细胞组成，具有内分泌功能，在控制葡萄糖稳态、新陈代谢和摄食行为方面至关重要。在胰岛内，内分泌激素还与支持细胞(内皮细胞、神经元、免疫细胞)和调节细胞功能和生存的二级信号分子形成复杂的旁分泌网络。这些信号的调节对糖尿病的发展、进展和治疗干预具有潜在的后果。胰岛β细胞缺失、内源性胰岛素分泌减少和胰升血糖素分泌失调是1型和2型糖尿病的显著特征，这些症状不仅会影响血糖的全身调节，还会影响胰岛内细胞的功能和存活。先进的研究和技术揭示了新的胰岛生物学(细胞身份和转录组)，并确定了以前未被识别的旁分泌信号和机制(生长抑素和Ghrelin旁分泌作用)，同时改变了先前对胰岛内通信的看法。本文将对调节胰岛内分泌功能和存活的旁分泌信号、糖尿病中发生的干扰和功能障碍以及保护胰岛β细胞质量和功能的潜在治疗靶点进行综述。
The pancreatic islet is a dense cellular network comprised of several cell types with endocrine function vital in the control of glucose homeostasis, metabolism, and feeding behaviour. Within the islet, endocrine hormones also form an intricate paracrine network with supportive cells (endothelial, neuronal, immune) and secondary signaling molecules regulating cellular function and survival. Modulation of these signals has potential consequences for diabetes development, progression, and therapeutic intervention. Beta cell loss, reduced endogenous insulin secretion, and dysregulated glucagon secretion are hallmark features of both type 1 and 2 diabetes that impact systemic regulation of glucose, but also contribute to the function and survival of cells within the islet. Advancing research and technology has revealed new islet biology (cellular identity and transcriptomes) and identified previously unrecognized paracrine signals and mechanisms (somatostatin and ghrelin paracrine actions), while shifting prior views of intra-islet communication. This review will summarize the paracrine signals regulating islet endocrine function and survival, the disruption and dysfunction that occurs in diabetes, and potential therapeutic targets to preserve beta cell mass and function.
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影响因子：
9.3
作者：
Baron M;Veres A;Wolock SL;Faust AL;Gaujoux R;Vetere A;Ryu JH;Wagner BK;Shen-Orr SS;Klein AM;Melton DA;Yanai I
通讯作者：
Yanai I
影响因子：
29
作者：
Ackermann AM;Moss NG;Kaestner KH
通讯作者：
Kaestner KH
DOI：
10.1113/jp274581
发表时间：
2018-01-15
期刊：
The Journal of physiology
影响因子：
--
作者：
Briant LJB;Reinbothe TM;Spiliotis I;Miranda C;Rodriguez B;Rorsman P
通讯作者：
Rorsman P
影响因子：
7.7
作者：
Banarer, S;McGregor, VP;Cryer, PE
通讯作者：
Cryer, PE
影响因子：
7.7
作者：
Braun M;Ramracheya R;Bengtsson M;Clark A;Walker JN;Johnson PR;Rorsman P
通讯作者：
Rorsman P