Emotional and neurobehavioural status in chronic pain patients
Emotional and neurobehavioural status in chronic pain patients
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慢性疼痛患者的情绪和神经行为状态
DOI：
10.1155/2011/825636
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发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
Opler, Mark G. A.
中科院分区：
文献类型：
--
作者：
He Shuchang;He Mingwei;Opler, Mark G. A.
目的：调查慢性疼痛患者的情绪和神经行为状态。
方法：对15名男性慢性下腰痛患者和15名健康对照受试者进行了约6个月的研究。使用视觉模拟量表测量疼痛。采用世界卫生组织神经行为核心测试组合（NCTB）评估环境和职业暴露的神经行为影响。
结果：视觉模拟量表结果显示，慢性疼痛患者报告的疼痛程度适中（平均[±标准差]为62.0 ± 10.8），而对照受试者未报告可测量的疼痛。通过NCTB发现，疼痛患者的消极情绪状态得分，包括愤怒 - 敌意、抑郁 - 沮丧、疲劳 - 惰性和紧张 - 焦虑，显著高于对照受试者。相比之下，慢性疼痛患者的积极情绪状态（活力 - 活动）得分低于对照组。慢性下腰痛患者的圣安娜敏捷性和追踪瞄准II测试的NCTB得分低于对照组。其他NCTB子测试的得分，包括数字广度、本顿视觉保持和数字符号测试，与对照组相比无显著差异。
结论：慢性下腰痛患者比对照组有更多的消极情绪和更少的积极情绪。这些患者在协调和反应时间方面也表现出神经运动缺陷。需要进一步的研究来检查慢性疼痛患者可能的神经机制，并研究潜在的干预策略。
OBJECTIVE: To investigate the emotional and neurobehavioural status of patients suffering from chronic pain.METHODS: Fifteen male patients with chronic lower back pain and 15 healthy control subjects were studied for approximately six months. Pain was measured using a visual analogue scale. The WHO Neurobehavioral Core Test Battery (NCTB) was used to assess neurobehavioural effects of environmental and occupational exposures.RESULTS: Visual analogue scale results demonstrated a modest range of reported pain (mean [+/- SD] 62.0 +/- 10.8) in chronic pain patients, whereas control subjects reported no measurable pain. With the NCTB, it was found that scores of negative mood state, including anger-hostility, depression-dejection, fatigue-inertia and tension-anxiety in pain patients were significantly higher than scores in the control subjects. By contrast, scores of positive mood state (vigour-activity) in chronic pain patients were lower than those in the control group. The NCTB scores of the Santa Ana Dexterity and Pursuit Aiming II tests in chronic lower back pain patients were lower than those of the control group. Scores for other NCTB subtests, including the Digit Span, Benton Visual Retention and Digit Symbol tests, were not significantly different compared with controls.CONCLUSIONS: Chronic lower back pain patients had more negative mood and less positive mood than controls. These patients also demonstrated neuromotor deficits in coordination and reaction time. Further studies are required to examine possible neurological mechanisms and research potential intervention strategies for patients suffering from chronic pain.