Biocatalytic combinatorial synthesis.
Biocatalytic combinatorial synthesis.
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DOI：
10.1016/s0968-0896(99)00145-5
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发表时间：
1999-10
影响因子：
3.5
通讯作者：
J. Krstenansky;Y. Khmelnitsky
中科院分区：
文献类型：
--
作者：
J. Krstenansky;Y. Khmelnitsky
组合生物催化，基于生物合成步骤的组合使用而不是试剂的组合使用的原理，提供了组合化学的补充方法，其单独使用或与合成有机转化结合使用，提供了获得单独通过化学合成手段不易获得的类似物的途径。特别是这种方法的问题和战略进行了讨论。给出的例子证明这些原则，以及实现化学，区域和立体选择性的独特优势，在温和的反应条件下，生物催化方法提供。
Combinatorial biocatalysis, based on a principle of the combinatorial use of biosynthetic steps rather than the combinatorial use of reagents, offers a complementary approach to combinatorial chemistry, which, used individually or in connection with synthetic organic transformations, provides access to analogues not readily accessible by chemical synthetic means alone. The issues and strategies particular to this approach are discussed. Examples are given demonstrating these principles as well as the unique advantages of achieving chemo-, regio- and stereoselectivity under mild reaction conditions that biocatalytic methods offer.