Epidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipients.
Epidemiology, risk factors, and outcomes of Clostridium difficile infection in kidney transplant recipients.
复制标题
肾移植受者中艰难梭菌感染的流行病学，危险因素和结果。
DOI：
10.1111/tid.12030
复制
发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Marr K
中科院分区：
文献类型：
--
作者：
Neofytos D;Kobayashi K;Alonso CD;Cady-Reh J;Lepley D;Harris M;Desai N;Kraus E;Subramanian A;Treadway S;Ostrander D;Thompson C;Marr K
We sought to describe the epidemiology and risk factors for Clostridium difficile infection (CDI) among kidney transplant recipients (KTR) between 1 January 2008 and 31 December 2010. A single-institution retrospective study was conducted among all adgbult KTR with CDI, defined as a positive test for C. difficile, by a cell cytotoxic assay for C. difficile toxin A or B or polymerase chain reaction test for toxigenic C. difficile. Among 603 kidney transplants performed between 1 January 2008 and 31 December 2010, 37 (6.1%) patients developed CDI: 12 (of 128; 9.4%) high-risk (blood group incompatible and/or anti-human leukocyte antigen donor-specific antibodies) vs. 25 (of 475; 5.3%, P=0.08) standard-risk patients. The overall rate of CDI increased from 3.7% in 2008 to 9.4% in 2010 (P = 0.05). The median time to CDI diagnosis was 9 days, with 27 (73.0%) patients developing CDI within the first 30 days after their transplant, and 14 (51.8%) developing CDI within 7 days. A case-control analysis of 37 CDI cases and 74 matched controls demonstrated the following predictors for CDI among KTR: vancomycin-resistant Enterococcus colonization before transplant (odds ratio [OR]: 3.6, P=0.03), receipt of an organ from a Centers for Disease Control high-risk donor (OR: 5.9, P =0.006), and administration of high-risk antibiotics within 30 days post transplant (OR: 6.6, P=0.001). CDI remains a common early complication in KTR, with rates steadily increasing during the study period. Host and transplant-related factors and exposure to antibiotics appeared to significantly impact the risk for CDI among KTR.
登录
查看更多内容
影响因子：
158.5
作者：
McDonald, LC;Killgore, GE;Gerding, DN
通讯作者：
Gerding, DN
影响因子：
120.7
作者：
Kelly, Ciaran P.
通讯作者：
Kelly, Ciaran P.
影响因子：
11.8
作者：
Alonso, Carolyn D.;Treadway, Suzanne B.;Marr, Kieren A.
通讯作者：
Marr, Kieren A.
DOI：
10.1111/j.1399-3062.2004.00040.x
发表时间：
2004-03-01
期刊：
Transplant infectious disease : an official journal of the Transplantation Society
影响因子：
--
作者：
Keven, K;Basu, A;Shapiro, R
通讯作者：
Shapiro, R
影响因子：
3.1
作者：
Albright, Jeffrey B.;Bonatti, Hugo;Hellinger, Walter
通讯作者：
Hellinger, Walter