High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide.
High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide.
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DOI：
10.1039/b406882c
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发表时间：
2004-10
影响因子：
4.9
通讯作者：
T. Matsuda;Kazunori Watanabe;T. Harada;Kaoru Nakamura;Yoshitaka Arita;Yukihiro Misumi;S. Ichikawa;T. Ikariya
中科院分区：
文献类型：
--
作者：
T. Matsuda;Kazunori Watanabe;T. Harada;Kaoru Nakamura;Yoshitaka Arita;Yukihiro Misumi;S. Ichikawa;T. Ikariya
一种新的连续流scCO（2）方法用于外消旋醇的动力学拆分，可以用固定化脂肪酶进行，以导致高达99%ee的相应光学活性乙酸酯和高达99%ee的未反应醇的定量混合物，其中光学活性化合物的产率与使用scCO（2）的相应间歇反应相比提高了400倍以上。
A novel continuous-flow scCO(2) process for kinetic resolution of racemic alcohols can be performed with an immobilized lipase to lead to a quantitative mixture of the corresponding optically active acetates with up to 99% ee and unreacted alcohols with up to 99% ee, in which the productivity of the optically active compounds was improved by over 400 times compared to the corresponding batch reaction using scCO(2).