Mechanisms of inactivation of hypothalamic regulatory hormones
Mechanisms of inactivation of hypothalamic regulatory hormones
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下丘脑调节激素失活的机制
DOI：
10.1016/0303-7207(79)90054-6
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发表时间：
1979
影响因子：
4.1
通讯作者：
J. A. Kelly
中科院分区：
文献类型：
--
作者：
E. Griffiths;J. A. Kelly
本文综述了促甲状腺激素释放激素、促黄体生成激素释放激素和生长抑素这三种下丘脑调节激素的酶失活机制，以及这些肽酶在神经内分泌调控中可能的生理意义。应用酶的位置标准（在生物合成、释放、作用、消除和排泄的位点）、酶的适当的生化特性和酶活性在生理环境中的变化都表明肽酶可以有助于控制下丘脑激素的释放和作用的机制。除了它们的生理功能之外，酶还可以直接参与某些病理状况。有证据表明，降解调节激素的酶可能参与激素激活和失活的过程。继续调查的肽酶可能会导致更好地了解这些下丘脑多肽激素的内分泌和其他假定的功能。
The mechanisms of enzymic inactivation of thyrotropin-releasing hormone, luteinizing hormone-releasing hormone and somatostatin, the three fully-characterized hypothalamic regulatory hormones, and the possible physiological significance of the peptidases in neuroendocrine control has been reviewed. Application of the criteria of enzyme location (at the sites of biosynthesis, release, action, elimination and excretion), appropriate biochemical characteristics of the enzymes and changes in enzyme activity in physiological circumstances all suggest that the peptidases can contribute to the mechanisms controlling the hypothalamic hormones' release and actions. Besides their physiological function, the enzymes may also be directly involved in certain pathological conditions. There is evidence to indicate that the enzymes degrading the regulatory hormones may participate in the process of hormone activation as well as inactivation. A continuing investigation of the peptidases may lead to a better understanding of the established endocrine and other putative functions of these hypothalamic polypeptide hormones.