Impaired subcutaneous adipocyte lipogenesis is associated with systemic insulin resistance and increased apolipoprotein B/AI ratio in men and women
Impaired subcutaneous adipocyte lipogenesis is associated with systemic insulin resistance and increased apolipoprotein B/AI ratio in men and women
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DOI：
10.1111/j.1365-2796.2007.01811.x
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发表时间：
2007-07-01
影响因子：
11.1
通讯作者：
Lofgren, P.
中科院分区：
文献类型：
--
作者：
Hoffstedt, J.;Forster, D.;Lofgren, P.
目标。研究皮下脂肪细胞脂肪生成与代谢综合征组成部分（全身性胰岛素抵抗、血脂异常和高血压）之间的关系。设计和设置。一项基于大学医院的横断面研究，383名受试者（303名女性和80名男性）的BMI范围很广（18-53 kg m(-2)）。体外脂肪细胞脂肪生成（基础和最大胰岛素刺激后）与HOMA-IR之间存在强烈的负相关（r = -0.42至-0.56,P < 0.0001, r = -0.37至-0.44,P < 0.001，分别为女性和男性）。使用胰岛素耐量试验（K-ITT）测量的胰岛素敏感性也与脂肪细胞脂肪生成相关（r = 0.47-0.57, P < 0.0001，女性；r = 0.52-0.70, P < 0.001，男性）。血浆载脂蛋白B/ ai比值与女性（r = -0.41 ~ 0.51, P < 0.0001）和男性（r = -0.49 ~ -0.55, P < 0.0001）的脂肪细胞脂肪生成呈负相关。女性脂肪细胞脂肪生成与血压呈显著负相关（r = -0.27 ~ -0.28, P < 0.0002,），而男性无显著负相关（P = 0.08 ~ 0.09）。在调整脂肪细胞体积、体重指数、腰臀比或年龄的差异后，所有相关性仍然显著（P < 0.01）。皮下脂肪细胞脂肪生成与全身胰岛素抵抗、血浆载脂蛋白B/ ai比和血压呈负相关，支持脂肪细胞功能受损本身可能有助于代谢综合征发展的观点。
Objectives. To study the association between subcutaneous fat cell lipogenesis and components of the metabolic syndrome (systemic insulin resistance, dyslipidaemia and hypertension).Design and setting. A university hospital-based cross-sectional study of 383 subjects (303 women and 80 men) with a wide range of BMI (18-53 kg m(-2)).Results. Strong negative correlations between in vitro fat cell lipogenesis (basal and after maximal insulin stimulation) and HOMA-IR were present in both genders (r = -0.42 to -0.56, P < 0.0001 and r = -0.37 to -0.44, P < 0.001, for women and men respectively). Insulin sensitivity measured using the insulin tolerance test (K-ITT) was also correlated with adipocyte lipogenesis (r = 0.47-0.57, P < 0.0001, women, r = 0.52-0.70, P < 0.001, men). Plasma apolipoprotein B/AI-ratio negatively associated with fat cell lipogenesis in women (r = -0.41 to-0.51, P < 0.0001,) and men (r = -0.49 to -0.55, P < 0.0001). The negative relationship of fat cell lipogenesis with blood pressure was significant in women (r = -0.27 to -0.28, P < 0.0002,) but not in men (P = 0.08-0.09). All correlations remained significant after adjusting for differences in fat cell volume, body mass index, waist- to hip- ratio or age (P < 0.01).Conclusions. Subcutaneous adipocyte lipogenesis is negatively associated with systemic insulin resistance, plasma apolipoprotein B/AI-ratio and blood pressure supporting the view that impaired fat cell function per se may contribute to the development of the metabolic syndrome.