Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy
Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy
复制标题
接受连续肾脏替代治疗的危重儿科患者的头孢吡肟药代动力学
DOI：
10.1128/aac.02006-18
复制
发表时间：
2019
影响因子：
4.9
通讯作者：
A. Akcan Arikan
中科院分区：
文献类型：
--
作者：
Gideon Stitt;Jennifer L. Morris;Lindsay Schmees;Joseph R. Angelo;A. Akcan Arikan
这项回顾性研究包括接受头孢吡肟治疗的连续静脉-静脉血液透析滤过（CVVHDF）的儿科重症监护病房患者。计算高于 MIC 一倍（fT>1×MIC）和四倍推定 MIC（fT>4×MIC）8μg/ml 的游离药物浓度。摘要 这项回顾性研究包括接受头孢吡肟治疗的连续静脉-静脉血液透析滤过 (CVVHDF) 的儿科重症监护病房患者。计算高于 MIC 一倍（fT>1×MIC）和四倍推定 MIC（fT>4×MIC）8μg/ml 的游离药物浓度。 4 名患者每 6 至 12 小时接受 48 至 64mg/kg 体重的剂量。三名患者达到 100% fT>1×MIC，第四名患者达到 98% fT>1×MIC。对于接受 CVVHDF 治疗的危重患者，应考虑进行治疗药物监测。
This retrospective study included pediatric intensive care unit patients receiving continuous veno-venous hemodiafiltration (CVVHDF) being treated with cefepime. The free drug concentration above one time the MIC (fT>1×MIC) and four times a presumed MIC (fT>4×MIC) of 8 μg/ml were calculated. ABSTRACT This retrospective study included pediatric intensive care unit patients receiving continuous veno-venous hemodiafiltration (CVVHDF) being treated with cefepime. The free drug concentration above one time the MIC (fT>1×MIC) and four times a presumed MIC (fT>4×MIC) of 8 μg/ml were calculated. Four patients received doses ranging from 48 to 64 mg/kg of body weight every 6 to 12 h. Three patients achieved 100% fT>1×MIC, with the fourth patient achieving 98% fT>1×MIC. Therapeutic drug monitoring should be considered for critically ill patients receiving cefepime on CVVHDF.