Short-term, low-dose, non-steroidal anti-inflammatory drug application diminishes premature ovulation in natural-cycle IVF
Short-term, low-dose, non-steroidal anti-inflammatory drug application diminishes premature ovulation in natural-cycle IVF
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DOI：
10.1016/j.rbmo.2011.12.002
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发表时间：
2012-03-01
影响因子：
4
通讯作者：
Kato, Osamu
中科院分区：
文献类型：
--
作者：
Kawachiya, Satoshi;Matsumoto, Tsunekazu;Kato, Osamu
在一家私人不孕不育中心进行了一项回顾性队列研究，以评估自然周期IVF（nIVF）治疗中非甾体抗炎药（NSAID）的使用。对2009-2010年期间进行的1865个一级nIVF周期进行了评价。在排卵风险较高的周期中以非随机方式给予低剂量、触发后NSAID，在触发日检测到即将发生的LH峰。主要结果指标为过早排卵率、每个预定周期的胚胎移植率和每个胚胎移植的临床妊娠率和活产率。使用NSAID与每个计划周期的排卵过早风险显著降低（3.6% vs 6.8%，校正OR 0.24，95%CI 0.15-0.39，P < 0.0001）和胚胎移植率较高（46.8% vs 39.5%，校正OR 1.38，95%CI 1.06-1.61，P = 0.012）相关。临床妊娠率（39.1%与35.9%）和每次胚胎移植的活产率（31.3%与31.4%）相当。在这项回顾性研究中，短期低剂量NSAID应用通过减少不必要的过早排卵率和增加达到胚胎移植的周期比例，对nIVF周期产生了积极影响。(C)2011年，爱思唯尔有限公司出版的生殖保健有限公司。版权所有。
A retrospective cohort study was conducted in a private infertility centre to evaluate the use of non-steroidal anti-inflammatory drugs (NSAID) in natural-cycle IVF (nIVF) treatment. A total of 1865 first-rank nIVF cycles performed during 2009-2010 were evaluated. Low-dose, post-trigger NSAID was administered in a non-randomized way in cycles at higher ovulation risk where an imminent LH surge was detected on triggering day. Main outcome measures were premature ovulation rate, embryo transfer rate per scheduled cycle and clinical pregnancy and live birth rates per embryo transfer. NSAID use was associated with a significantly lower risk of premature ovulation (3.6% versus 6.8%, adjusted OR 0.24, 95% CI 0.15-0.39, P < 0.0001) and higher embryo transfer rate (46.8% versus 39.5%, adjusted OR 1.38, 95% CI 1.06-1.61, P = 0.012) per scheduled cycle. Clinical pregnancy (39.1% versus 35.9%) and live birth rates per embryo transfer (31.3% versus 31.4%) were comparable. In this retrospective series, short-term low-dose NSAID application positively influenced nIVF cycles by diminishing the rate of unwanted premature ovulations and increasing the proportion of cycles reaching embryo transfer. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.