Genome evolution mediated by Ty elements in Saccharomyces
Genome evolution mediated by Ty elements in Saccharomyces
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DOI：
10.1159/000084939
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发表时间：
2005-01-01
影响因子：
1.7
通讯作者：
Garfinkel, DJ
中科院分区：
文献类型：
--
作者：
Garfinkel, DJ
移动的遗传元件如何塑造真核基因组是一个关键的进化问题，当移动的DNA序列被证明包含大约一半的人类基因组时，这个问题得到了更广泛的关注。虽然酿酒酵母没有这种“基因组肥胖”，但LTR-反转录转座子的五个家族Ty 1、Ty 2、Ty 3、Ty 4和Ty 5元件占其基因组的约3%。完整的基因组序列的可用性从几个酵母属物种，包括密切相关的狭义组的成员，染色体进化，物种形成和生殖隔离的分子机制分析提供了新的机会。在这篇综述中，我提出了关键的实验，从前和当前的基因组测序时代表明Ty元素如何介导基因组进化。版权所有（c）2005 S. Karger AG，巴塞尔。
How mobile genetic elements molded eukaryotic genomes is a key evolutionary question that gained wider popularity when mobile DNA sequences were shown to comprise about half of the human genome. Although Saccharomyces cerevisiae does not suffer such "genome obesity", five families of LTR-retrotransposons, Ty1, Ty2, Ty3, Ty4, and Ty5 elements, comprise about 3% of its genome. The availability of complete genome sequences from several Saccharomyces species, including members of the closely related sensu stricto group, present new opportunities for analyzing molecular mechanisms for chromosome evolution, speciation, and reproductive isolation. In this review I present key experiments from both the pre- and current genomic sequencing eras suggesting how Ty elements mediate genome evolution. Copyright (c) 2005 S. Karger AG, Basel.