Characterization of the regional distribution of skeletal muscle adipose tissue in type 2 diabetes using chemical shift-based water/fat separation
Characterization of the regional distribution of skeletal muscle adipose tissue in type 2 diabetes using chemical shift-based water/fat separation
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DOI：
10.1002/jmri.23512
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发表时间：
2012-04-01
影响因子：
4.4
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Karampinos, Dimitrios C.;Baum, Thomas;Majumdar, Sharmila
目的：显示使用基于化学位移的水/脂肪分离评估骨骼肌脂肪组织的空间分布的可行性，并表征2型糖尿病（T2 DM）患者与健康年龄匹配对照组相比小腿肌间脂肪组织（IMAT）区室化的差异。材料和方法：一项基于化学位移的水/脂肪分离方法使用多回波3D扰相梯度回波序列应用于64例患者的研究，包括35例健康对照和29例T2 DM受试者。基于手动分割来定义掩模，以计算不同隔室内的脂肪体积，包括皮下脂肪组织（SAT）区域和六个肌肉区域。IMAT被分为两个区室，代表肌肉区域内的脂肪（intraMF）和肌肉区域之间的脂肪（interMF）。结果：与健康对照组相比，T2 DM受试者的SAT体积较低（P = 4 x 10（-5））。两组间的IMAT体积无统计学显著差异。然而，intraMF体积标准化的IMAT体积是更高的糖尿病患者相比，对照组（P = 0.006）。结论：化学位移为基础的水/脂肪分离，使量化的脂肪体积内的局部肌肉区域，显示IMAT区域分布是显着不同的T2 DM相比，正常对照组。
Purpose: To show the feasibility of assessing the spatial distribution of skeletal muscle adipose tissue using chemical shift-based water/fat separation and to characterize differences in calf intermuscular adipose tissue (IMAT) compartmentalization in patients with type 2 diabetes mellitus (T2DM) compared to healthy age-matched controls.Materials and Methods: A chemical shift-based water/fat separation approach using a multiecho 3D spoiled gradient echo sequence was applied in a study of 64 patients, including 35 healthy controls and 29 subjects with T2DM. Masks were defined based on manual segmentations to compute fat volume within different compartments, including regions of subcutaneous adipose tissue (SAT) and six muscular regions. IMAT was divided into two compartments representing fat within the muscular regions (intraMF) and fat between the muscular regions (interMF). Two-sample Student's t-tests were used to compare fat volumes between the two groups.Results: The subjects with T2DM had a lower volume of SAT compared to the healthy controls (P = 4 x 10(-5)). There was no statistically significant difference in the IMAT volume between the two groups. However, the intraMF volume normalized by the IMAT volume was higher in the diabetics compared to the controls (P = 0.006).Conclusion: Chemical shift-based water/fat separation enables the quantification of fat volume within localized muscle regions, showing that the IMAT regional distribution is significantly different in T2DM compared to normal controls.