The complex link between influenza and severe sepsis.
The complex link between influenza and severe sepsis.
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DOI：
10.4161/viru.27103
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发表时间：
2014-01-01
期刊：
影响因子：
5.2
通讯作者：
Kalil AC
中科院分区：
文献类型：
--
作者：
Florescu DF;Kalil AC
严重脓毒症传统上与细菌性疾病相关。虽然真菌和寄生虫也可以引起败血症，但它们明显不如细菌引起的常见。然而，病毒正在成为全球严重脓毒症的一个日益增长的原因。在这些病毒中，流感正在跨越所有地理边界，并正在造成更大的流行病和大流行。因此，全世界越来越多的重症患者因流感病毒直接或间接引起的继发性细菌感染而出现严重脓毒症。本文旨在提供流感和严重脓毒症之间联系的病理生理学和临床更新。
Severe sepsis is traditionally associated with bacterial diseases. While fungi and parasites can also cause sepsis, they are significantly less common than bacterial causes. However, viruses are becoming a growing cause of severe sepsis worldwide. Among these viruses, influenza is crossing all geographic boundaries and is causing larger epidemics and pandemics. As a consequence, more critically ill patients with severe sepsis caused directly by influenza viruses, or indirectly by influenza-induced secondary bacterial infections are being admitted to hospitals worldwide. This manuscript aims to provide a pathophysiological and clinical update on the link between influenza and severe sepsis.