Round cell variant of measles virus: neurovirulence and pathogenesis of acute encephalitis in newborn hamsters.
Round cell variant of measles virus: neurovirulence and pathogenesis of acute encephalitis in newborn hamsters.
复制标题
麻疹病毒的圆形细胞变体：新生仓鼠急性脑炎的神经毒力和发病机制。
DOI：
10.1016/0042-6822(86)90331-4
复制
发表时间：
1986
期刊：
影响因子：
3.7
通讯作者：
Carrigan,DR
中科院分区：
文献类型：
--
作者：
Carrigan,DR
麻疹病毒的亚急性硬化性全脑炎（SSPE）毒株先前已被证明由两种相互关联但可分离的病毒变体组成。其中之一，合胞体基因或S变体，类似于麻疹病毒的缺陷，细胞相关株;而另一个，圆细胞诱导或RC变体，在细胞培养中诱导高产感染。现在有报道称，S变异体在新生仓鼠中的神经毒性比RC变异体更强，并且病毒在感染的CNS组织中的复制分两个阶段进行。在感染早期，产生主要由RC变体组成的无细胞病毒。后来，随着抗病毒抗体的出现，无细胞病毒迅速消失，只留下类似于S变体的细胞相关病毒。感染组织中病毒抗原表达的定量表明，感染状态的这种变化与抗原调节无关，而是优先消除RC变体感染细胞的结果。
A subacute sclerosing panencephalitis (SSPE) strain of measles virus has been previously shown to be composed of two interrelated but separable viral variants. One of these, the syncytiagenic or S variant, resembles defective, cell-associated strains of measles virus; while the other, the round cell inducing or RC variant, induces a highly productive infection in cell culture. It is now reported that the S variant is more neurovirulent in newborn hamsters than the RC variant and that viral replication in infected CNS tissues occurs in two phases. Early in the infection cell-free virus, composed primarily of the RC variant, is produced. Later, coincident with the appearance of antiviral antibody, cell-free virus rapidly disappears, leaving behind only cell-associated virus which resembles the S variant. Quantification of viral antigen expression in the infected tissues suggests that this change in the state of infection is not associated with antigenic modulation, but rather is the result of preferential elimination of RC variant infected cells.