Trichoblastoma is the most common neoplasm developed in nevus sebaceus of Jadassohn - A clinicopathologic study of a series of 155 cases
Trichoblastoma is the most common neoplasm developed in nevus sebaceus of Jadassohn - A clinicopathologic study of a series of 155 cases
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DOI：
10.1097/00000372-200004000-00004
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发表时间：
2000-04-01
影响因子：
1.1
通讯作者：
Yus, ES
中科院分区：
文献类型：
--
作者：
Jaqueti, G;Requena, L;Yus, ES
Jadassohn皮脂痣是一种合并了表皮、毛囊、皮脂腺和顶分泌腺异常的错构瘤。传统上，几种类型的皮肤肿瘤与这种错构瘤有关，基底细胞癌是最常见的恶性肿瘤。我们研究了155例Jadassohn皮脂痣与临床病理的关系。发现与患者年龄有关的几种组织病理学改变。在我们的系列研究中，我们没有发现任何真正的基底细胞癌病例。相反，可以看到几个原始毛囊诱导和毛母细胞瘤的例子。在我们的Jadassohn皮脂瘤系列中发现的其他皮肤错构瘤、增生和肿瘤包括乳头汗管囊腺瘤、皮脂瘤、大汗腺囊肿、孔瘤、不同组织病理类型的疣(经典型疣、毛囊瘤和结缔组织增生性毛囊瘤)、原始毛囊诱导和导管诱导。在我们的系列中，没有发现恶性肿瘤的例子。根据这些发现，这种错构瘤的经典推荐治疗方法，包括早期切除以防止恶性发展，似乎是不合适的。
Nevus sebaceus of Jadassohn is a hamartoma that combines epidermal, follicular, sebaceous, and apocrine gland abnormalities. Classically several types of cutaneous neoplasms have been associated with this hamartoma, with basal cell carcinoma being the most frequently described malignancy. We studied a series of 155 examples of nevus sebaceus of Jadassohn with clinicopathologic correlation. Several histopathologic changes related to the age of the patients were found. In our series, we could not identify any cases of authentic basal cell carcinoma. In contrast, several examples of primitive follicular induction and of trichoblastomas were seen. Other cutaneous hamartomas, hyperplasias, and neoplasms found in our series of nevus sebaceus of Jadassohn included syringocystadenoma papilliferum, sebomatricoma, apocrine gland cyst, poroma, different histopathologic variants of warts (classic warts, tricholemmoma, and desmoplastic tricholemmoma), primitive follicular induction, and ductal induction. In our series, no examples of malignant neoplasms were identified. On the basis of these findings, the classically recommended treatment for this hamartoma, which consists of early excision to prevent the development of malignancy, seems to be inappropriate.