Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia
Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia
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DOI：
10.1038/s41375-023-01912-1
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发表时间：
2023-04-29
期刊：
影响因子：
11.4
通讯作者：
Zeng, Hui
中科院分区：
文献类型：
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作者：
Deng, Suqi;Du, Juan;Zeng, Hui
急性髓性白血病（AML）细胞通过糖酵解重编程代谢葡萄糖。然而，葡萄糖摄取如何在白血病细胞和骨髓微环境的其他细胞之间分配尚未研究。我们使用正电子发射断层扫描（PET）示踪剂F-18氟脱氧葡萄糖（[F-18]-FDG）探针和转录组学分析来检测MLL-AF 9诱导的小鼠模型中骨髓微环境中不同细胞的葡萄糖摄取。白血病细胞具有最大的葡萄糖摄取，白血病干细胞和祖细胞具有最大的葡萄糖摄取。我们还显示了抗白血病药物对白血病细胞数量和葡萄糖摄取的影响。我们的数据表明，如果我们的观察结果在AML患者中得到验证，则靶向葡萄糖摄取是AML的潜在治疗策略。
Acute myeloid leukaemia (AML) cells metabolise glucose by glycolysis-based re-programming. However, how glucose uptake is partitioned between leukaemia cells and other cells of the bone marrow micro-environment is unstudied. We used a positron emission tomography (PET) tracer F-18 fluorodeoxyglucose ([F-18]-FDG) probe and transcriptomic analyses to detect glucose uptake by diverse cells in the bone marrow micro-environment in a MLL-AF9-induced mouse model. Leukaemia cells had the greatest glucose uptake with leukaemia stem and progenitor cells having the greatest glucose uptake. We also show the effects of anti-leukaemia drugs on leukaemia cell numbers and glucose uptake. Our data suggest targeting glucose uptake as a potential therapy strategy in AML if our observations are validated in humans with AML.