Current and future imaging modalities for multiple myeloma and its precursor states.
Current and future imaging modalities for multiple myeloma and its precursor states.
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DOI：
10.3109/10428194.2011.573036
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发表时间：
2011-09
影响因子：
2.6
通讯作者：
Landgren O
中科院分区：
文献类型：
--
作者：
Tan E;Weiss BM;Mena E;Korde N;Choyke PL;Landgren O
传统上，骨骼测量一直是检测多发性骨髓瘤中溶骨性骨病的标准方法。除了对溶骨性病变的检测敏感性较差外，该方法不能识别髓外病变和局灶性骨髓病变，也不能测量对治疗的反应。新的成像技术如计算机断层扫描(CT)、磁共振成像(MRI)和分子成像如18F-FDG正电子发射断层扫描CT(18F-FDG PET/CT)和18F-氟化钠正电子发射断层扫描CT(18F-NaF PET/CT)的应用有可能克服这些局限性，并提供前体状态和多发性骨髓瘤的预后信息。同样有希望的是使用动态增强磁共振成像(DCE MRI)来测量血管通透性，这是骨髓增生症的一个重要特征。本文综述了多发性骨髓瘤及其前体状态的新的成像方法的现状和未来可能发挥的作用。
Traditionally, the skeletal survey has been the standard modality for the detection of osteolytic bone disease in multiple myeloma. In addition to its poor sensitivity for the detection of osteolytic lesions, this modality is not able to identify extramedullary lesions and focal bone marrow involvement, nor measure response to therapy. The application of novel imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and molecular imaging such as fluorine-18 fluorodeoxyglucose positron emission tomography CT (18F-FDG PET/CT) and fluorine-18 sodium fluoride positron emission tomography CT (18F-NaF PET/CT) has the potential to overcome these limitations as well as provide prognostic information in precursor states and multiple myeloma. Also promising is the use of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) to measure vascular permeability, an important feature of myelomagenesis. This review summarizes the current status and possible future role of novel imaging modalities in multiple myeloma and its precursor states.
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影响因子：
2.1
作者：
Gleeson, T. G.;Moriarty, J.;Eustace, S. J.
通讯作者：
Eustace, S. J.
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作者：
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通讯作者：
Barlogie, Bart
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作者：
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通讯作者：
Hawkins, R
影响因子：
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作者：
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通讯作者：
Metzgeroth, Georgia
影响因子：
11.4
作者：
Durie, B. G. M.;Harousseau, J-L;Rajkumar, S. V.
通讯作者：
Rajkumar, S. V.