Ratio-images calculated from interictal positron emission tomography and single-photon emission computed tomography for quantification of the uncoupling of brain metabolism and perfusion in epilepsy.
Ratio-images calculated from interictal positron emission tomography and single-photon emission computed tomography for quantification of the uncoupling of brain metabolism and perfusion in epilepsy.
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根据发作间期正电子发射断层扫描和单光子发射计算机断层扫描计算的比率图像，用于量化癫痫中脑代谢和灌注的解偶联。
DOI：
10.1111/j.1499-1654.2000.001560.x
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发表时间：
2000
期刊：
影响因子：
5.6
通讯作者：
Spencer,SS
中科院分区：
文献类型：
--
作者：
Zubal,IG;Avery,RA;Stokking,R;Studholme,C;Corsi,M;Dey,H;Seibyl,JP;Spencer,SS
目的应用图像处理技术对发作间期正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）脑图像进行处理，通过计算代表灌注和代谢之间耦合程度的功能图像来辅助定位致痫灶。这两个功能的解偶联已被证明是一个特点的致痫组织在颞叶epilepsy，并有可能作为一个诊断措施，定位在其他areaset. MethodsInterictalPET（18）F-FDG）和interictalSPECT（（99 m）Tc-HMPAO）扫描从11例癫痫患者。代谢和灌注图像进行三维空间配准，并计算功能比率图像。这些功能图叠加到同一个病人的磁共振成像anatomic.ResultsIn所有患者的三维渲染，平均均匀的灌注代谢比在整个大脑的大部分显示近似恒定的值。然而，癫痫区（手术证实）表现出一个区域的灌注/代谢升高的灰质。ConclusionsAlthough hypometabolism在PET图像中观察到在大多数这些患者，计算功能比率图像表现出局部病灶，在某些情况下不能单独观察到的PET图像。比率图像也产生了一个定量测量的解耦现象。
PurposeImage processing techniques were applied to interictal positron emission tomography (PET) and single-photon emission computed tomography (SPECT) brain images to aid in the localization of epileptogenic foci by calculating a functional image that represents the degree of coupling between perfusion and metabolism. Uncoupling of these two functions has been demonstrated to be a characteristic of epileptogenic tissue in temporal lobe epilepsy and has the potential to serve as a diagnostic measure for localization in other areas as well.MethodsInterictal PET ((18) F-FDG) and interictal SPECT ((99m) Tc-HMPAO) scans were acquired from 11 epilepsy patients. The metabolism and perfusion images were three-dimensionally spatially registered, and a functional ratio-image was computed. These functional maps are overlaid onto a three-dimensional rendering of the same patient's magnetic resonance imaging anatomy.ResultsIn all patients, an average uniform perfusion-to-metabolism ratio showed approximately constant values throughout most of the whole brain. However, the epileptogenic area (confirmed on surgery) demonstrated an area of elevated perfusion/metabolism in the grey matter.ConclusionsAlthough hypometabolism in the PET image was observed in most of these patients, the calculation of a functional ratio-image demonstrated localized foci that in some cases could not be observed on the PET image alone. The ratio-image also yields a quantitative measure of the uncoupling phenomenon.