Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion
Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion
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DOI：
10.1097/pas.0000000000001235
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发表时间：
2019-06-01
影响因子：
5.6
通讯作者：
Bastian, Boris C.
中科院分区：
文献类型：
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作者：
Yeh, Iwei;Busam, Klaus J.;Bastian, Boris C.
激活NTRK1融合已被描述为跨Spitz肿瘤光谱的致癌事件。在此，我们报告了38例融合了NTRK1的Spitz肿瘤。这些Spitz肿瘤具有独特的组织病理学特征，其特征是细丝状网脊，呈细长、分枝状，真皮黑素细胞呈玫瑰花样排列，黑素细胞体积明显缩小，向真皮下移。这些特征与其他基因定义的Spitz肿瘤亚型不同，可以帮助显微镜诊断，并有助于在需要靶向治疗的罕见患者中优先选择分子测试的病例。
Activating NTRK1 fusions have been described as oncogenic events across the spectrum of Spitz tumors. Herein we report a series of 38 Spitz tumors with NTRK1 fusion. These Spitz tumors have distinctive histopathologic features characterized by filigree- like rete ridges which are elongated, thin and branched, dermal melanocytes arranged in a rosette- like configuration, and marked diminishment of melanocyte size with descent into the dermis. These features are distinct from those of other genetically defined subtypes of Spitz tumors and can aid in microscopic diagnosis and help prioritize in case selection for molecular testing in the rare patients that need targeted therapy.