Alternate leg movement amplifies locomotor-like muscle activity in spinal cord injured persons
Alternate leg movement amplifies locomotor-like muscle activity in spinal cord injured persons
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DOI：
10.1152/jn.00817.2004
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发表时间：
2005-02-01
影响因子：
2.5
通讯作者：
Nakazawa, K
中科院分区：
文献类型：
--
作者：
Kawashima, N;Nozaki, D;Nakazawa, K
现在人们普遍认识到，即使在脊髓损伤（SCI）患者瘫痪的下肢肌肉中，通过对双腿施加类似运动的运动也可以诱导肌肉活动。尽管在之前的研究中已经相当强调了与髋关节运动和身体负荷相关的传入输入的重要作用，但“交替”腿部运动模式的贡献尚未得到充分研究。这项研究旨在调查交替腿部运动在多大程度上影响这种“类似运动”的肌肉活动。使用步态训练器对 10 名完整的 SCI 受试者进行膝锁腿部摆动运动。采用以下三种不同的实验条件：1）双边交替腿部运动，2）单侧腿部运动，3）双边同步（同相）腿部运动。在所有实验条件下，被动腿部运动都会诱导所有 SCI 受试者的比目鱼肌和腓肠肌内侧头以及 10 名 SCI 受试者中的 8 名股二头肌的 EMG 活动。另一方面，在胫骨前肌和股直肌中没有观察到肌电图活动。这些激活肌肉的肌电图水平（通过整合右腿记录的校正肌电图活动来量化），双侧交替腿部运动明显大于单侧和双侧同步运动，尽管右髋关节和踝关节运动在所有实验条件下都是相同的。此外，不同条件下施加到腿部的负载模式的差异无法解释双侧交替腿部运动条件下肌电图活动的增强。这些结果表明，交替腿部运动产生的感觉信息在放大下肢诱导的类似运动的肌肉活动方面发挥着重要作用。
It is now well recognized that muscle activity can be induced even in the paralyzed lower limb muscles of persons with spinal cord injury (SCI) by imposing locomotion-like movements on both of their legs. Although the significant role of the afferent input related to hip joint movement and body load has been emphasized considerably in previous studies, the contribution of the "alternate" leg movement pattern has not been fully investigated. This study was designed to investigate to what extent the alternate leg movement influenced this "locomotor-like" muscle activity. The knee-locked leg swing movement was imposed on 10 complete SCI subjects using a gait training apparatus. The following three different experimental conditions were adopted: 1) bilateral alternate leg movement, 2) unilateral leg movement, and 3) bilateral synchronous (in-phase) leg movement. In all experimental conditions, the passive leg movement induced EMG activity in the soleus and medial head of the gastrocnemius muscles in all SCI subjects and in the biceps femoris muscle in 8 of 10 SCI subjects. On the other hand, the EMG activity was not observed in the tibialis anterior and rectus femoris muscles. The EMG level of these activated muscles, as quantified by integrating the rectified EMG activity recorded from the right leg, was significantly larger for bilateral alternate leg movement than for unilateral and bilateral synchronous movements, although the right hip and ankle joint movements were identical in all experimental conditions. In addition, the difference in the pattern of the load applied to the leg among conditions was unable to explain the enhancement of EMG activity in the bilateral alternate leg movement condition. These results suggest that the sensory information generated by alternate leg movements plays a substantial role in amplifying the induced locomotor-like muscle activity in the lower limbs.