Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management.
Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management.
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DOI：
10.2147/cmar.s35175
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发表时间：
2013
影响因子：
3.3
通讯作者：
Demorrow S
中科院分区：
文献类型：
--
作者：
Leyva-Illades D;Demorrow S
G蛋白偶联受体(GPCRs)调节大量的细胞过程。本文综述了GPCRs的一般特征及其在生理条件下的作用。此外，它还描述了GPR55的生理和病理生理功能的最新知识，以及如何利用它作为治疗靶点来对抗各种癌症。
G protein-coupled receptors (GPCRs) modulate a vast array of cellular processes. The current review gives an overview of the general characteristics of GPCRs and their role in physiological conditions. In addition, it describes the current knowledge of the physiological and pathophysiological functions of GPR55, an orphan GPCR, and how it can be exploited as a therapeutic target to combat various cancers.