Efficient γ-aminobutyric acid editing at 3T without macromolecule contamination: MEGA-SPECIAL
Efficient γ-aminobutyric acid editing at 3T without macromolecule contamination: MEGA-SPECIAL
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DOI：
10.1002/nbm.1688
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发表时间：
2011-12-01
影响因子：
2.9
通讯作者：
Jezzard, Peter
中科院分区：
文献类型：
--
作者：
Near, Jamie;Simpson, Robin;Jezzard, Peter
在体内检测氨基丁酸(GABA)的MRS最常用的方法之一是兆点分辨光谱(MEGA-PRESS)技术。然而，使用超级压力机精确定量GABA是由于大分子共振的光谱共同编辑而变得复杂的。在这篇文章中，提出了一种新的脉冲序列，它可以在3T编辑GABA，同时去除大分子污染。这个序列结合了传统的巨型编辑方案和特殊的本地化技术，因此被命名为巨型特殊。模拟和模型实验表明，与巨型印刷机相比，这种新方法提供了更高的GABA编辑效率，体内结果表明有效地去除了大分子污染。在一项对五名健康志愿者枕叶的研究中，发现经大分子校正的GABA/肌酸比率为0.093+/-0.007(平均+/-标准差)，而在大分子校正前，该比率被发现为0.173+/-0.013。版权所有(C)2011 John Wiley&Sons，Ltd.
One of the most commonly used methods for in vivo MRS detection of ?-aminobutyric acid (GABA) is the MEGA-point-resolved spectroscopy (MEGA-PRESS) technique. However, accurate quantification of GABA using MEGA-PRESS is complicated by spectral co-editing of macromolecular resonances. In this article, a new pulse sequence is presented which enables GABA editing at 3T with the removal of macromolecule contamination. This sequence combines the conventional MEGA editing scheme with the SPECIAL localisation technique, and is therefore named MEGA-SPECIAL. Simulations and phantom experiments indicate that this new approach provides improved GABA editing efficiency relative to MEGA-PRESS, and in vivo results demonstrate effective removal of macromolecule contamination. In a study of the occipital lobe of five healthy volunteers, the macromolecule-corrected GABA/creatine ratio was found to be 0.093 +/- 0.007 (mean +/- standard deviation), whereas prior to macromolecule correction, the ratio was found to be 0.173 +/- 0.013. Copyright (C) 2011 John Wiley & Sons, Ltd.