Place learning in the Morris water task: Making the memory stick
Place learning in the Morris water task: Making the memory stick
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DOI：
10.1101/lm.146106
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发表时间：
2006-05-01
影响因子：
2
通讯作者：
Rudy, Jerry W.
中科院分区：
文献类型：
--
作者：
Bolding, Kevin;Rudy, Jerry W.
虽然Morris水任务已被用于数百项地点学习的研究中，但迄今为止还没有系统的关于地点记忆保持的研究。我们报告说，保留，作为测量的选择性搜索行为的探针试验，是优秀的保留时间间隔很短（5- 10分钟）。然而，性能迅速恶化，因此通过类似于4 h的搜索不再是选择性的。额外的实验表明，在较长的保留间隔的选择性搜索，提高了插入训练试验块之间的差距，但这种效果是一个非单调函数的间隔分隔试验块。我们的实验还表明，第一组实验的位置（房间A或房间B）与长期保留无关。记忆调制理论框架可能为理解这些发现提供有用的方法。
Although the Morris water task has been used in hundreds Of Studies of place learning, there have been no systematic studies of retention of the place memory. We report that retention, as measured by selective search behavior on a probe trial, is excellent when the retention interval is short (5-10min). However, performance rapidly deteriorates, so that by similar to 4 h the search is no longer selective. Additional experiments revealed that selective search at longer retention intervals was improved by inserting gaps between blocks of training trials, but this effect was a non-monotonic function of the interval separating trial blocks. Our experiments also revealed that the location of the first block of trials (Room A or Room B) was irrelevant to long-term retention. A memory modulation theoretical framework may provide a useful way to understand these findings.